Polygenic risk scores give inaccurate and highly inconsistent results in embryo selection, researchers find

Polygenic risk scores (PRSs) are estimates of an individual’s susceptibility to a specific complex trait obtained by aggregating the effects of dozens, thousands, and potentially millions of genetic variants associated with that specific trait into a single figure. Some private companies now market PRS embryo screening to prospective parents through the use of in vitro fertilization and pre-implantation genetic testing.

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