Ground-glass opacities on CT lung cancer imaging encouraging prognostic factor in non-small cell lung cancer: Study

The study found the presence of ground-glass opacities (GGO) rather than pure-solid nodules on computed tomography (CT) lung cancer imaging to be an encouraging prognostic factor in non-small cell lung cancer.

“Minor-GGO elements on lung CT (equal to or less than 10%) were associated with a reduced likelihood of recurrence,” the researchers reported.

Ground-glass opacity, often observed on CT scans, represents areas of partial lung consolidation or infiltration without obscuring the underlying structures. While major GGO components have been extensively studied in the context of NSCLC, the significance of minor GGO components, defined as ≤ 10% of the tumor size, has remained relatively understudied until now.

To fill this knowledge gap, Meiling Li, Shanghai Jiao Tong University School of Medicine, Shanghai, China, and colleagues aimed to investigate the impact of a minor (≤10%) GGO component on the prognosis of clinical stage I NSCLC compared to pure-solid nodules.

The retrospective study included 382 patients (mean age, 61 years; 210 men) who underwent surgical resection between January 1, 2015, and December 31, 2015, for clinical stage I NSCLC appearing on preoperative chest CT as a nodule with a consolidation-to-tumor (CTR) ratio ≥0.9 and <1.0.

Nodules were independently assigned by two radiologists to a minor-GGO (≥0.9 CTR <1.0) or pure-solid (CTR=1.0) groups. Cancer-specific survival (CSS) and recurrence-free survival (RFS) were compared between groups. Cox proportional hazard models were used to evaluate associations with outcomes.

The study led to the following findings:

• The two radiologists agreed for all nodules’ classification into the minor-GGO (n=106) or pure-solid (n=276) groups.
• The mean CTR of the minor-GGO group was 0.93±0.02.
• Minor-GGO nodules, compared to pure-solid nodules, showed greater solid component diameter (2.68 versus 2.16 cm) and total nodule diameter (2.89 versus 2.16 cm).
• The minor-GGO group, in comparison with the pure-solid group, showed lower frequencies of visceral pleural invasion (6.6% versus 17.0%), pathologic lymph node involvement (4.7% versus 20.3%), and epidermal growth factor mutation (71.6% versus 39.9%).
• The minor-GGO group, compared to the pure-solid group, showed better 5-year RFS (83.4% vs 55.0%) and better 5-year CSS (92.4% vs 76.4%).
• In multivariable analysis adjusting for patient, imaging, pathologic, and genetic factors, a minor-GGO component was independently associated with a decreased likelihood of recurrence (HR=0.37) but not with the likelihood of CSS.

The findings showed that among patients with clinical stage I NSCLC, cancers with a minor-GGO component were linked with a better prognosis versus those with a pure-solid appearance.

“Radiologists encountering predominantly solid nodules on CT should carefully evaluate images for even a minor-GGO component given the favorable prognosis,” the researchers concluded.

Reference:

DOI: https://doi.org/10.2214/AJR.24.31283