CDC recommends Doxy pep to prevent bacterial STIS

The CDC recommends doxycycline postexposure prophylaxis (doxy PEP) as part of a comprehensive sexual health strategy to prevent sexually transmitted infections (STIs). Studies have shown that doxy PEP significantly reduces bacterial STIs, such as chlamydia and syphilis, particularly among men who have sex with men (MSM) and transgender women (TGW).

Doxy PEP should be taken as a 200 mg dose within 72 hours after sexual exposure, with the most benefit observed in those with a history of STIs in the past 12 months. These guidelines are based on a systematic review of randomized controlled trials and expert consultations, demonstrating its feasibility and acceptability.