Ammonia buildup kills liver cells but can be prevented using existing drug

High levels of ammonia kill liver cells by damaging the mitochondria that power the cells. But this can be prevented using an existing drug due to start clinical trials, finds a new study in mice led by researchers from UCL.

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Calcium channel inhibition promotes cardiac regeneration, offering hope for heart failure treatment

Researchers report a discovery in cardiac regeneration that offers new hope for the treatment of ischemic heart failure. Published in npj Regenerative Medicine, the study reveals a novel approach to promoting cardiomyocyte proliferation. The researchers are from the Michael E. DeBakey Department of Surgery at Baylor College of Medicine, the QIMR Berghofer Medical Research Institute in Brisbane, Australia, and collaborating institutions.

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Researchers spearhead efforts to establish guidelines for personalized nutrition approaches

Personalized nutrition (PN) has gained popularity in recent years as a customized approach to health outcomes. PN combines biomedical, genetic, and lifestyle data to provide individualized recommendations, and a plethora of companies offer various forms of health screenings, apps, programs, products, and diet advice.

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Genome-edited stem cells reveal new hope for obesity treatment without muscle loss

In a study published in Nature Communications, researchers at the Beijing Institute of Stem Cells and Regeneration (BISCRM) and the Institute of Zoology (IOZ) have cracked the code of the notorious FTO gene, reconciling its dual role in obesity and muscle growth. The revelation could improve obesity and diabetes treatments, potentially offering an alternative to popular GLP-1 receptor agonists that may cause undesirable muscle wasting.

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‘Candidates wasting seats will be debarred from counselling’- AFMS warns NEET PG candidates, check details

New Delhi- “Any candidate who causes a lapse/ wastage of seat will be debarred from participating in counselling for admission in to AFMS Institutions in the upcoming years and be liable to face any action including legal from the competent authority”- the Armed Forces Medical Services (AFMS) recently stated in a notice issued for Priority- III Candidates (Medical Officers Sponsored By Para Military Organizations And Other Govt Of India Organizations) for PG medical admissions this year at AFMS institutes 2024-27 academic year.

The institute said, “Candidature of Priority-III candidates who choice-fill/ select subjects for which they are not sponsored vide the Sponsorship Certificates forwarded to this office by their parent organization are liable to be summarily rejected.”

In this regard please refer to para 19 & 23 (c) of the Information Bulletin for PG Courses (MD/MS/DNB/MDS) in AFMS Institutions through NEET PG 2024 & NEET MDS 2024’. The sections say:

19. A candidate shall not be eligible to take admission in AFMS Institutions if he/ she
has ‘cancelled’/ ‘failed to report for admission within the stipulated time’/ ‘vacated a
seat mid course in the past’, which has resulted in lapse/ wastage of a seat.

23 c) c) Priority-III candidates will be considered eligible for admission in AFMS
Institutions only for those subjects, which are mentioned in their sponsorship
certificate as forwarded by the respective sponsoring authority. In case a
Priority-III candidate is allotted a seat during the counselling conducted by the
MCC which is not mentioned in the Sponsorship Certificate forwarded by the
sponsoring organization, admission in AFMS PG Teaching Institutes would not
be granted and the candidate would be liable to suffer the consequences.

 It is further reiterated that any candidate who causes a lapse/ wastage of seat will be debarred from participating in counselling for admission in to AFMS Institutions in the upcoming years and be liable to face any action including legal from the competent authority, the AFMS said.

To view the official Notice, Click here : https://medicaldialogues.in/pdf_upload/notice-for-priority-iii-candidates-for-md-ms-dnb-courses-through-neet-pg-exam-2024-in-afms-institutions-for-the-academic-session-2024-2027-277488.pdf

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‘Assessors Did not Identify Any Deficiencies!’- DY Patil Medical College Pune says after NMC Letter

New Delhi: Soon after the National Medical Commission (NMC) sought action taken report from the DY Patil Medical College, Pune on several allegations, the college released a statement highlighting that the Commission’s assessors’ team did not find any violations during inspections.

Clarifying that during multiple inspections, no such deficiencies were identified, the college mentioned in its statement that it has already responded to the queries raised by NMC and it continues to comply with the regulations, reports Edex Live

Medical Dialogues had earlier reported that taking cognizance of several allegations concerning medical students, their training and the functioning of the institute, NMC recently directed the DY Patil Medical College, Pune to look into the matter and furnish an action taken report within a week.

NMC wrote to the medical college in this regard after receiving a complaint alleging several deficiencies in the medical college including infrastructure and space constraints, irregularities and financial concerns, stipend deductions, issues with the district residency programme, deficiencies in medical training and patient care, and concerns regarding surgical training.

Accordingly, in a letter dated 04.03.2025, NMC asked the college to immediately look into the matter and furnish an Action Taken Report to the Postgraduate Medical Education Board of the Commission within 7 days.

Also Read: Fake Files, Stipends deductions, Poor Training – DY Patil Medical College Pune Under NMC Scanner

As per the NMC letter, the college campus houses multiple institutes leading to “congestion and resource limitations” and it also lacks a playground and parking space for the resident doctors. Allegations were also raised claiming that the college was maintaining fake files, additional payments were being collected from students for faculties and resident publication, stipend deductions were being carried out arbitrarily, and fake scholarship documents were being submitted to the UGC. It was further alleged the medical college was inadequately implementing the District Residency Program. Besides, the complainant also highlighted deficiencies in medical training and patient care and concerns regarding surgical training.

The issue was also raised by the National President of the United Doctors’ Front (UDF) Dr Lakshya Mittal who shared copies of the NMC’s letter to the medical college.

However, the college has now defended itself clarifying that the NMC assessors did not find any deficiencies while conducting inspection at the medical college. 

Sharing a statement on the issue with Edex Live, the college mentioned, “Dr DY Patil Medical College, Hospital & Research Centre, Pimpri, Pune, is committed to excellence in medical education, infrastructure and patient care. We adhere to all regulatory standards and have consistently met the highest benchmarks in every inspection. The NMC follows a procedural approach in seeking clarifications for any queries raised. We categorically state that during multiple inspections, NMC assessors have not identified any deficiencies. We have responded to the NMC queries and continue to uphold regulatory compliance. Our institution remains committed to the highest standards of transparency, integrity and the relentless pursuit of medical excellence.”

Previously, the college was directed by the Postgraduate Medical Education Board (PGMEB) of the National Medical Commission (NMC) on 30.01.2025 to furnish its comments concerning the allegations of non-payment of stipends and mental harassment etc. Thereafter on 20.02.2025, the college informed that the complainant had collected all the documents and that the Complaint was false. However, NMC has observed that the college did not provide documentary proof for the payment of the stipend.

Also Read:NMC to introduce SOPs to address grievances on stipend, faculty, work hours

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Lupin unveils heart drug Rivaroxaban in US

Mumbai: Global pharma major Lupin Limited has announced that it has
launched
Rivaroxaban Tablets USP, 2.5 mg, following the final approval of its Abbreviated New Drug
Application (ANDA) from the US Food and Drug Administration (U.S. FDA).

Rivaroxaban Tablets USP, 2.5 mg, is bioequivalent to Xarelto Tablets, 2.5 mg of JanssenPharmaceuticals, Inc..

It is indicated 

• to reduce the risk of major cardiovascular events in patients with coronary artery disease (CAD)

• to reduce the risk of major thrombotic vascular events in patients with peripheral artery disease
(PAD), including patients after recent lower extremity revascularization due to symptomatic
PAD.


Rivaroxaban Tablets USP, 2.5 mg (RLD Xarelto) had estimated annual sales of USD 446 million in the
U.S. (IQVIA MAT January 2025).

Medical Dialogues team had earlier reported that Lupin had received approval from the U.S.FDA for its  ANDA, Sacubitril and Valsartan Tablets, 24 mg/26 mg, 49 mg/51 mg, and 97 mg/103 mg.

Read also: Lupin bags USFDA nod for Ipratropium Bromide Nasal Solution for rhinorrhea

Lupin Limited is a global pharmaceutical company headquartered in Mumbai, India, with products distributed in over 100 markets. Lupin specializes in pharmaceutical products, including branded and generic formulations, complex generics, biotechnology products, and active pharmaceutical ingredients. The company has a strong position in India and the U.S. across multiple therapy areas, including respiratory, cardiovascular, anti-diabetic, anti-infective, gastrointestinal, central nervous system, and women’s health. Lupin has 15 state-of-the-art manufacturing sites and 7 research centers globally.

Read also: Lupin secures place in Prestigious S&P Global Sustainability Yearbook 2025

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Rajasthan MLA highlights Stipend Violations, overwork, recruitment issues in Assembly

Jaipur: Rajasthan MLA and
Congress leader Dr. Shikha Meel Barala raised significant concerns
about the state’s healthcare system during the Assembly session on March 6, 2025, including the pending Ayushman Bharat claims. 

Among the concerns were inadequate medical education due to a lack of
faculty and infrastructure, excessive duty hours for resident doctors, stipend
violations in private medical colleges, delays in Rajasthan Medical Education
Society (RajMES) recruitment, and lack of transparency in transfer policies.

One of the major issues
raised was the delayed payments under the Ayushman Bharat scheme, leaving
numerous beneficiaries waiting for their rightful claims. Citing data obtained
through the Right to Information (RTI) Act by the United Doctors’ Front (UDF),
she underscored the urgent need for addressing these lapses in the
implementation of the government’s flagship health insurance program.

Medical Dialogues recently reported that a total outstanding amount of Rs 1,21,61,45,63,617 (₹1.21 lakh crore) remains unpaid to empanelled hospitals under the Ayushman Bharat scheme (AB-PMJAY), with more than 63 lakh pending claims yet to be cleared, revealed the data shared by the National Health Authority (NHA) in response to a Right to Information (RTI) application. 

Dr. Barala also spoke
about the exploitative working conditions of resident doctors, who are often
forced to work long hours beyond permissible limits, particularly in private
medical institutions where stipend violations are rampant. Additionally, she
criticized the lack of transparency in transfer policies and the slow
recruitment process under RajMES, which has left many positions in government
healthcare institutions vacant.

Another controversial
matter she brought up was the appointment of Dr. Pramod Yeole as the
Vice-Chancellor of Rajasthan University of Health Sciences (RUHS), Jaipur.
Yeole, a pharmacist from Maharashtra, was deemed unqualified to lead a medical
university, drawing widespread backlash from doctors’ associations across
Rajasthan. Dr. Barala expressed gratitude to the United Doctors’ Front (UDF)
for consistently bringing these issues to public attention and emphasized the
need for immediate reforms to ensure better healthcare delivery in the state.

Dr Lakshya Mittal,
National President of UDF, took to his X account and appreciated Dr Barala for
putting forward the issue in the assembly, “A powerful stand for medical
fraternity! Hon’ble MLA, Rajasthan Dr. Barala ma’am, MS (OBGY) fearlessly
raised key issues in Rajasthan Vidhan Sabha Assembly. United Doctors Front
(UDF) thanks her for being our voice. The fight for better healthcare &
medical education continues!”

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Karnataka aims for Zero Maternal deaths, allocates Rs 320 crore

Bengaluru: Karnataka Chief Minister Siddaramaiah on Friday announced a significant allocation of Rs 320 crore to reduce preventable maternal mortality rate to zero in the state.

Presenting his 16th state budget, he highlighted several health infrastructure improvement projects that will be implemented in the year 2025-26.

Noting that Karnataka will introduce a pioneering policy focused on preventing and treating burn injuries among women, the Chief Minister said, “This will be a first of its kind initiative in the country.”

According to the PTI report, Siddaramaiah said the government will develop a mission-mode programme to reduce preventable maternal-mortality in the State to minimum. To this end, Rs 320 crore has been provided.

Also Read:Maternal Mortality Rate significantly reduced in Meghalaya, thanks to MOTHER Policy: Conrad Sangma

“Obstetric services will be strengthened by equipping hospitals with all necessary equipment to treat and prevent severe postpartum hemorrhage by leveraging novel digital technology. To prevent anemia among pregnant women, nutrition kits, financial incentives and Vatsalya Kits for mothers will be distributed in backward districts. MCH specialists will be deputed in every taluka hospital through re-deployment of posts,” he said.

The maternal mortality cases in the state will be subject to the audit of the State Technical Expert Committee and its recommendations will be submitted to the State Empowered Committee, he said.

“Programmes to reduce maternal mortality will be formulated based on Committee’s directives,” he added.

Last year, the state had witnessed a number of maternal deaths leading to outrage.

He said that a state-of-the-art and well equipped 200 bedded hospital will be constructed at a cost of Rs150 crore in Bengaluru North Taluk while PHCs (Primary Health Centre) of the newly announced taluks of Hanur, Alanavar, Annigeri, Maski, Sirivar, Kapu, Babaleshwar, Kolhar, Cheluru and Terdal will be upgraded to Community Health Centres (CHC).

A new CHC will be established in Ponnampet.

“Taluka Hospitals in Maluru, Magadi, Kushalanagar, Koratagere, Jagaluru, Savanuru, Ramadurga and Savadatti and the district hospital in Davangere and Wenlock Hospital in Mangaluru will be renovated at a cost of Rs 650 crore,” he said.

The CM said a new medical college will be established at Puttur. To this end, action will be initiated to upgrade the present 100-bedded Taluka hospital during this year.

“‘Gruha Aarogya Scheme” implemented on a pilot basis in Kolar district in 2024-25 to screen and treat six non-communicable diseases will be extended to the entire state at the cost of Rs 100 crore, he said.

According to Siddaramaiah, a 200-bedded hospital will be established at Molakalmuru in Chitradurga district and a 400-bedded hospital will be established at Virajapete in Kodagu district and the Community Health Centre at Tagaduru in Mysuru district will be upgraded to a 100-bedded hospital.

District and Taluk hospitals which require extensive repairs will be renovated at a cost of Rs 183 crore in a phased manner.

“To provide quality health services, to improve the health indicators and strengthen health systems in Kalyana Karnataka region under the Kalyana Karnataka Comprehensive Health Scheme several initiatives have been undertaken at the cost of Rs. 873 crore,” he said, reports PTI.

Siddaramaiah said that a cancer diagnosis unit will be started in Bidar Government Medical College Hospital and Institutes modelled on NIMHANS will be established at Mysuru and Kalaburagi Medical Colleges each at a cost of Rs 100 crore.

A super specialty hospital will be set up under Koppal Institute of Medical Sciences at a cost of Rs 100 crore and a Kidwai Peripheral Cancer treatment unit will be set up on the campus of Rajiv Gandhi Super Specialty Hospital in Raichur at Rs 50 crore.

Also Read:India can lead in shaping Maternal and Child Healthcare Strategies for Developing Nations: PMNCH’s Rajat Khosla

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No Proposal for Maternity Hospital in Pulwama: Sakina Masood Itoo

Pulwama: During a legislative assembly session, MLA Waheed Ur Rehman Para from Pulwama raised a question regarding the construction of a 100-bed maternity hospital in Sirnoo village, Pulwama district, South Kashmir. In response, the Minister for Health and Medical Education, Sakina Masood Itoo, clarified that there is no proposal for such a hospital at present. 

Health Minister Itoo stated that maternal healthcare services for the people of Pulwama, including Sirnoo, are being provided at the District Hospital in Pulwama. She noted that, currently, there are no plans for a separate maternity hospital.

The minister further explained that the government’s current focus is on strengthening and consolidating the existing healthcare infrastructure rather than building new facilities. Itoo also mentioned that Jammu and Kashmir is home to around 4,000 healthcare institutions across primary, secondary, and tertiary levels.

According to a report by the Ministry of Health and Family Welfare (MoHFW), the region is performing better than the national average in terms of healthcare accessibility. The report states that Jammu and Kashmir have one healthcare institution for every 3,500 people, compared to the national average of one for every 6,000 people.

The health minister added that any future upgrades or new projects in the healthcare sector would be dependent on various factors, including population density, existing healthcare infrastructure, proximity to other healthcare facilities, and compliance with the Indian Public Health Standards (IPHS) norms for 2022.

Also Read: 2000-bed state-of-the-art hospital to come up in Chandigarh

According to Rising Kashmir, the health minister said, “Furthermore, a recent Finance Department order (10-F of 2025, dated January 11, 2025) has restricted the creation of new posts, limiting the scope for expanding health services through new constructions.

To improve healthcare services, the government has conceptualized a plan to strengthen the existing health infrastructure through rationalization of manpower, resource sharing, and digital healthcare initiatives. This includes the expansion of e-Sanjeevani and telemedicine facilities, using a hub-and-spoke model to enhance accessibility.”

The 100-bed maternity hospital in Sirnoo village has been a long-standing concern for local residents. According to reports, around 2018-19, several canals of state land on the outskirts of Sirnoo village were designated for the proposed hospital, and a signboard was even installed at the site to mark the location. Speaking to Rising Kashmir, an aged resident of Sirnoo said that a road to the site was also opened by the then-deputy commissioner Pulwama.

Also Read: 300-bedded hospital spanning over 25 acres to come up in Jharkhand

However, the project has seen no progress over the past six years, leading to growing concerns and frustrations among the local community. Following this, MLA Waheed Ur Rehman Para raised the issue in the legislative assembly, seeking clarification from the government on whether the proposal for the maternity hospital was still pending approval or if there were any plans to revive the project soon.

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