What is effect of Selectively Applying Face Mask Positive Pressure Ventilation in Preterm Infants in Delivery Room?

Recent study compared the effects of selectively applying a face mask only for positive pressure ventilation (PPV) versus routinely applying a face mask for continuous positive airway pressure (CPAP) in preterm infants in the delivery room. The researchers randomized infants born before 32 weeks of gestation into selective or routine groups. The primary outcome was the proportion of infants receiving face mask PPV in the delivery room. The results showed that there was no significant difference in face mask PPV rates between the selective group (64%) and the routine group (52%). This suggests that selectively applying a face mask for PPV only did not result in fewer preterm infants receiving PPV in the delivery room.

Impact of Face Mask Application on Spontaneous Breathing in Preterm Infants

The study sought to address the common practice of applying a face mask for breathing support to preterm infants despite most infants breathing spontaneously at birth. The research aimed to determine if the application of a face mask inhibits spontaneous breathing in newborns, leading to the need for PPV. The findings indicated that the timing and duration of PPV were similar in both groups, regardless of whether the face mask was selectively or routinely applied. The study also highlighted that more infants in the lower gestational age category tended to require PPV in the delivery room, indicating varying responses among infants based on gestational age.

Study Design and Methodologies

Moreover, the study design and methodologies were described in detail, including random assignment, data collection processes, and outcomes measured in the delivery room and neonatal intensive care unit. Exploratory outcomes such as duration of respiratory support, incidence of necrotizing enterocolitis, and abnormalities in cranial ultrasound were also assessed. The study acknowledged limitations such as the single-center design and potential for performance bias due to the lack of blinding of caregivers to group assignment.

Conclusion and Implications

Overall, the study provided valuable insights into the practice of applying face masks for respiratory support in preterm infants at birth. It emphasized the need for further research to better understand the association between mask application and respiratory outcomes in newborns. The detailed description of the study’s protocol, outcomes, and limitations contributes to the existing literature on neonatal resuscitation practices and informs future research in this area.

Key Points

– The study compared selectively applying a face mask for positive pressure ventilation (PPV) versus routinely applying a face mask for continuous positive airway pressure (CPAP) in preterm infants born before 32 weeks of gestation.

– There was no significant difference in face mask PPV rates between the selective group (64%) and the routine group (52%), suggesting that selectively applying a face mask for PPV only did not result in fewer preterm infants receiving PPV in the delivery room.

– The impact of face mask application on spontaneous breathing in preterm infants was assessed to determine if applying a face mask inhibits spontaneous breathing, leading to the need for PPV. – Timing and duration of positive pressure ventilation (PPV) were similar in both groups regardless of whether the face mask was selectively or routinely applied.

– Infants in the lower gestational age category tended to require PPV in varying responses suggesting differences based on gestational age.

– The study detailed the methodologies including random assignment, data collection processes, and outcomes measured in the delivery room and neonatal intensive care unit, assessing exploratory outcomes such as duration of respiratory support, incidence of necrotizing enterocolitis, and abnormalities in cranial ultrasound, while acknowledging limitations like the single-center design and potential performance bias due to lack of blinding of caregivers to group assignment.

Reference –

CaitríOna M Ní Chathasaigh et al. (2024). Selective Or ROUTINE Face Mask Application For Breathing Support Of Preterm Infants At Birth: A Randomised Trial.. *Resuscitation*, 110467. https://doi.org/10.1016/j.resuscitation.2024.110467

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Better semen quality is linked to men living longer

Men’s semen quality is associated with how long they live, according to a study of nearly 80,000 men, published in Human Reproduction.

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Global study finds more than 130% rise in postmenopausal osteoarthritis over past three decades

The global number of cases of osteoarthritis, as well as the disability associated with the condition, has risen by more than 130% over the past three decades among women who have gone through the menopause, indicates a data analysis spanning 1990 to 2021, and published in the journal BMJ Global Health.

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Resistance exercise may be best type for tackling insomnia in older age, data analysis suggests

Resistance or muscle-strengthening exercise, using weights or the body itself, may be the best type of exercise for tackling insomnia in older age, suggests a pooled data analysis of the available research, published in the open-access journal Family Medicine and Community Health.

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Video: Assistive-feeding robot gets tested outside the lab

The mechanics of eating are more complex than they might appear. For about a decade, researchers in the Personal Robotics Lab at the University of Washington have been working to build a robot that can help feed people who can’t eat on their own.

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New knowledge may help make medicines taste better for the most bitter-sensitive

Many medicines taste so bitter that some people avoid taking them. To help with the bad taste, flavors and sweeteners are added to modify the taste and make it more acceptable. However, not everyone has the same sense of taste and sensitivity toward bitterness or gets the same relief from the modifiers.

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Obesity Needs Multifactorial Effort with Collective Endeavour: Jitendra Singh

New Delhi: ”Obesity is a multifactorial challenge and needs multifactorial preventive strategies”. 

This was stated yesterday by Union Minister Dr Jitendra Singh, who is also a Professor of Medicine and a renowned Diabetologist, while underscoring the urgent need for a multifaceted and collective approach to combat the growing obesity crisis in India.

Addressing the ‘National Obesity Summit”, organized by the Confederation of Indian Industry (CII) on the occasion of “World Obesity Day”, the Minister emphasised that obesity is not just a lifestyle issue but a major public health challenge that requires coordinated efforts from the government, industry, the medical fraternity and also the society.

Citing alarming statistics, Dr Jitendra Singh pointed out that India ranks second globally in childhood obesity, with over 1.4 crore children affected. “We often take pride in having chubby babies, but this comes at a cost. Central obesity, particularly among Indians, is an independent and a serious health risk factor,” he said. 

Also Read:PM Modi nominates 10 prominent personalities to raise awareness about Obesity

He further elaborated that obesity significantly contributes to non-communicable diseases such as type-2 diabetes mellitus, cardiovascular disorders, and fatty liver disease, making it imperative to take preventive action. 

The Union Minister acknowledged the Indian phenotype’s unique vulnerability to central obesity, citing studies that show even lean-looking Indians carry a higher percentage of visceral fat compared to their Western counterparts. “Our traditional attire may mask central obesity, but that does not eliminate the associated health risks,” he remarked.

Highlighting Prime Minister Narendra Modi’s advocacy for healthier lifestyles, Dr Jitendra Singh recalled how the Prime Minister has frequently addressed obesity in his Mann Ki Baat broadcasts and public interactions, even urging citizens to reduce their food intake by 10%. “PM Modi has a remarkable ability to transform messages into mass movements, as seen in campaigns like Swachh Bharat and the COVID-19 response. A similar approach is needed to tackle obesity,” he said.

Dr. Jitendra Singh expressed concern over the rising prevalence of obesity despite widespread awareness campaigns and medical advancements. “On one hand, we talk about fitness and wellness, but on the other, obesity rates continue to surge. This paradox must be addressed with scientific rigor and societal commitment,” he noted. He also highlighted the economic burden obesity places on families, with many patients struggling to afford long-term treatment for metabolic disorders.

Emphasizing the need for a strategic response, Dr. Jitendra Singh called for an industry-government partnership to develop cost-effective, universal screening models for obesity and metabolic diseases. “We cannot leave this fight solely to diabetologists or obesity specialists. It requires a national commitment involving policymakers, medical experts, and industry leaders,” he asserted. He suggested a public-private model where routine health screenings include obesity markers, particularly in hospital settings, to facilitate early diagnosis and intervention.

Dr. Jitendra Singh also cautioned against new quick-fix solutions, such as weight-loss injections and fad diets, stressing the importance of sustainable lifestyle changes. “The real solution lies in self-discipline—understanding our body, regulating our diet, and adopting a balanced approach to health,” he said. He humorously pointed out how dietary habits have evolved, with intermittent fasting and exotic diet plans becoming fashionable trends. “Our grandmothers would have been amused by the concept of ‘5 PM eating schedules’ and calorie counting apps,” he quipped.

Concluding his address, Dr. Jitendra Singh called upon all stakeholders to take immediate action rather than waiting for annual summits to reiterate the same concerns. “Obesity is not just a personal concern; it is a national responsibility. As we envision India in 2047, we must ensure that our young population remains healthy, productive, and free from preventable lifestyle diseases,” he asserted.

The summit saw participation from leading medical experts, policymakers, and industry representatives, all of whom echoed the need for collective action to address obesity at a systemic level.

Also Read:Union Minister Jitendra Singh Calls for SCTIMST to Emerge as Global Hub for Neurosurgery and Cardiovascular Research

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Frequent Daytime Napping Linked to Higher Cardiovascular Risk in Diabetes, finds Study

A new study identified daytime napping at frequent intervals to be linked to higher risks of major adverse cardiovascular events (MACE) and death in type 2 diabetics. The study published in Diabetes Research and Clinical Practice found that individuals who tended to nap daily had a substantially greater risk of cardiovascular complications, such as myocardial infarction, heart failure, and stroke. The study was conducted by Xiu H. and fellow researchers.

The research sought to assess the influence of daytime napping on cardiovascular events in patients with type 2 diabetes. A sample of 21,129 UK Biobank participants who had no MACE or cancer at baseline were included. Information on sleep behaviors such as daytime napping frequency and overall sleep duration was obtained via a baseline questionnaire.

To establish the relationship between daytime napping and unfavorable outcomes, researchers used Cox proportional hazards regression models. The main outcomes measured were MACE, all-cause mortality, and cardiovascular disease (CVD)-specific mortality. MACE was a composite of myocardial infarction, heart failure, and stroke.

Key Findings

Over a mean follow-up of 11.9 years, the study found:

• 5,611 MACE cases

• 3,854 all-cause deaths

• 1,839 CVD-specific deaths

Relative to those who never or seldom napped, those who typically napped had substantially higher risks:

• MACE: Hazard Ratio (HR) 1.39 (95% CI: 1.08-1.65)

• Myocardial infarction: HR 1.44 (95% CI: 1.01-1.92)

• Heart failure: HR 1.33 (95% CI: 1.07-1.64)

• Stroke: HR 1.57 (95% CI: 1.06-2.33)

• All-cause mortality: HR 1.28 (95% CI: 1.01-1.60)

• CVD mortality: HR 1.33 (95% CI: 0.97-1.94)

Daytime napping on a frequent basis is linked with a higher risk of cardiovascular events and death in patients with type 2 diabetes. The results highlight the need to observe sleep habits in diabetic patients, particularly those with long sleep duration.

Reference:

Yang, X. H., Liu, Y., Jiang, X. X., Zhang, Z. X., Lu, Y. J., Fu, C. S., Jin, H. M., & Ye, Z. B. (2025). Daytime napping and risk of incident main adverse cardiovascular events and mortality among adults with type 2 diabetes. Diabetes Research and Clinical Practice, 112067, 112067. https://doi.org/10.1016/j.diabres.2025.112067

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Fact Check: Can Warts/Skin Tag Be Removed in Just 2 Days with Natural Ingredients?

An Instagram post claims that warts can be removed in just 2 days by using slaked lime (Chuna) and baking soda. The claim is False. 

Claim

The reel posted by the Instagram user ai.pure_health claims that warts/skin tags can be removed in just 2 days by using slaked lime (Chuna) and baking soda. The reel states, “This ₹1 remedy can completely eliminate warts/skin tags from the root—in just 1 minute! You just need to take half a teaspoon of slaked lime (the one used in betel leaves). Then, add half a teaspoon of baking soda to it. Finally, add two to three drops of water and mix it well. Now, apply this mixture only on the wart. Within just 2 days, the wart will dry up and fall off without you even noticing.”

The post has 184,469 likes and can be accessed here.

Fact Check

The claim is False. There is no proven evidence that slaked lime and baking soda can remove warts or skin tags in 2 days. For safe and effective treatment, it’s best to seek medical advice instead of relying on unverified remedies.

What are warts?

Warts are benign skin growths caused by the human papillomavirus (HPV). They are highly contagious and can develop at any age, though they are most commonly seen in children and teenagers. These growths form when the virus enters the skin through small cuts or abrasions, leading to excessive cell production that thickens the outer skin layer.

Although most warts are harmless and often resolve on their own within weeks or months, some may cause discomfort, such as itching, tightness, or pain, particularly when located on the soles of the feet. Additionally, some warts may contain tiny black or brown specks, which are actually clotted blood from broken capillaries beneath the skin.

What are Skin Tags?

Skin tags are benign, soft skin growths that commonly develop on the neck, eyelids, and underarms. They may be the same colour as the skin or appear darker, and if irritated, they can turn pink or red. These small growths typically form in areas where friction occurs, such as where the skin rubs against itself, clothing, or jewellery. Common locations include under the breasts, on the neck, eyelids, groin, and underarms. Individuals with diabetes, metabolic syndrome, or a genetic predisposition are at a higher risk of developing skin tags.

What are the Health Benefits of Slaked Lime and Baking Soda?

Limestone (CaCO₃) is a naturally occurring industrial mineral that is widely used across various industries. Its primary component is calcium carbonate (CaCO₃). One of the most important uses of limestone is in the production of lime (CaO), which is obtained by calcining limestone—a process where limestone is heated at high temperatures to drive off carbon dioxide (CO₂).

When lime (CaO), also known as unslaked lime or quicklime, is mixed with water, it undergoes a chemical reaction called slaking, resulting in the formation of slaked lime (Ca(OH)₂.

Slaked lime (calcium hydroxide, Ca(OH)₂) plays a significant role in enhancing calcium intake, particularly in regions where it is used to fortify (adding extra nutrients) staple foods like rice. Calcium is essential for bone health, growth, and development, and adequate intake helps prevent and manage conditions like rickets, a disorder caused by calcium deficiency. 

Baking soda, also known as sodium bicarbonate, breaks down into carbon dioxide, water, and salt when used. The carbon dioxide gas it releases causes dough to rise quickly, making it a popular ingredient in baking bread and cakes. Additionally, it enhances athletic performance by helping the body balance acidity levels and reducing muscle fatigue. It also plays a role in lowering bad cholesterol and blood sugar while boosting good cholesterol. For individuals with kidney disease, baking soda can slow disease progression and support better nutritional health. Moreover, it helps cancer patients undergoing chemotherapy by alleviating symptoms like nausea and diarrhoea.

Can Warts/Skin Tag Be Removed in Just 2 Days by Using Slaked Lime (Chuna) and Baking Soda?

Studies show that slaked lime boosts calcium intake when added to staple foods like rice, while baking soda helps balance acidity, reduce muscle fatigue, and support heart health, but there is no scientific evidence or medical consensus to support the claim that warts/skin tag can be removed in just 2 days by using slaked lime and baking soda.

A study in the Journal of Ayurvedic and Herbal Medicine found that Kaalaani Kalimbu is a well-known Siddha cream used to remove hard skin, warts, corns, and skin tags through chemical cauterization. It contains limestone, arsenic trisulfide, copper sulfate, mercuric perchloride, lead sulfide, and beeswax. The study mentions limestone, which is the compound used to produce slaked lime (calcium hydroxide), but it does not directly refer to slaked lime itself. The study also highlights chemical cauterization, a process that involves strong and potentially harmful chemicals, which should not be used by the general public without medical supervision.

Another study in the Journal of Emerging Technologies and Innovative Research tested a mixture of sodium bicarbonate and castor oil (1:1 ratio) on warts after cutting them at the base. The results showed that sodium bicarbonate has anti-wart properties, possibly because it makes the affected area too alkaline for the human papillomavirus (HPV) to survive, grow, and spread. But, the study does not confirm that sodium bicarbonate alone can completely remove warts after application.

These studies do not mention any direct role of slaked lime or baking soda in removing warts or skin tags within 2 days. Additionally, there is no medical consensus within the medical community supporting the claim that applying lime and baking soda can achieve this result in 2 days.

Dr. Priyanka Kuri, Consultant Dermatology, Aster Whitefield Hospital, Bengaluru, told Medical Dialogues, “Many patients use slaked lime and baking soda to remove warts, but both are irritants that can burn the skin, causing redness, peeling, and post-inflammatory hyperpigmentation. The concentrated mixtures seen online can be especially harmful. Instead, dermatologists perform safer medical treatments like radiofrequency cautery, which effectively removes warts with minimal scarring. Using slaked lime and baking soda is strongly discouraged to prevent skin damage and long-term marks.”

Dr. Prateek Chauhan, MBBS, MD (Dermatologists, Leprologists), Ultra Health Skin Clinic, Delhi, added, “Applying slaked lime and baking soda to warts can cause skin irritation, burns, and pigmentation issues. While home remedies are popular, they may do more harm than good, especially when used in concentrated forms. It’s always best to consult a dermatologist for safe and effective wart removal, rather than risking unintended skin damage with unverified treatments.”

Medical Dialogues Final Take

While slaked lime and baking soda have various health benefits, there is no reliable basis to support the claim that they can remove warts or skin tags within 2 days. Warts and skin tags require proper medical treatment, and using home remedies without guidance may cause skin irritation, burns, or complications. It is always best to consult a doctor before trying any treatment for skin concerns.

Hence, the claim that warts/skin tags can be removed in just 2 days by using slaked lime and baking soda is False.

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Double Sequential External Defibrillation and VC Defibrillation Increase Survival in Cardiac Arrest Patients: Study

Canada: A recent study published in the Resuscitation Journal highlighted the benefits of alternate defibrillation strategies in reducing the duration of ventricular fibrillation (VF) and improving survival rates.

Double sequential external defibrillation (DSED) and vector change (VC) defibrillation reduced the duration of VF compared to standard shocks (83 & 98 seconds versus 108 seconds, respectively). DSED demonstrated the highest rates of return of spontaneous circulation (17.6% versus 5.3%) and survival to hospital discharge (10.2% versus 3.5%) compared to standard shocks, indicating their potential to improve cardiac arrest outcomes,” the researchers reported.

Double sequential external defibrillation, a technique that delivers two defibrillation shocks in quick succession from separate devices, demonstrated the most promising results. Survival following out-of-hospital cardiac arrest (OHCA) is closely linked to the duration of ventricular fibrillation. However, the effect of vector change defibrillation and DSED on VF duration has not been investigated thoroughly. Considering this, Sheldon Cheskes, Institute of Medical Sciences, University of Toronto, Toronto, Ontario, Canada, and colleagues aimed to evaluate the impact of VC and DSED on VF duration and defibrillation effectiveness.

For this purpose, the researchers conducted a secondary analysis of patients enrolled in the Double Sequential External Defibrillation for Refractory VF RCT. They evaluated ECG recordings following each shock, measuring VF duration (median, IQR) and assessing shock outcomes. To compare VF duration among different groups, the Kruskal-Wallis test was applied, followed by post-hoc pairwise comparisons using Dunn’s test with Bonferroni correction. Shock outcomes were analyzed using chi-square tests.

The study revealed the following findings:

  • One thousand eight hundred forty-two shocks were analyzed among 342 patients, including 834 shocks following three failed standard shocks (429 standard, 218 VC, 187 DSED).
  • Median VF duration was significantly shorter with DSED (83 [0, 120] s) and VC (98 [0, 120] s) compared to standard shocks (108 [38, 120] s).
  • The rate of ROSC was higher for DSED (17.6%) and VC (14.2%) compared to standard shocks (5.3%).
  • Survival to hospital discharge was greater for DSED (10.2%) and VC (7.3%) than for standard shocks (3.5%).
  • The proportion of shocks in which VF was not terminated was significantly lower for DSED (29.9%) than standard shocks (40.6%).

“In the DOSE VF RCT, patients who received DSED and VC shocks experienced a shorter VF duration than those given standard shocks. Both DSED and VC shocks were significantly more effective in achieving ROSC and improving survival to hospital discharge,” the researchers wrote.

“The reduced VF duration observed with these alternative defibrillation strategies may help explain the survival benefits seen in the trial,” they concluded.

Reference:

Cheskes, S., Drennan, I. R., Turner, L., Pandit, S. V., Walker, R. G., & Dorian, P. (2025). The impact of alternate defibrillation strategies on time in ventricular fibrillation. Resuscitation, 110549. https://doi.org/10.1016/j.resuscitation.2025.110549

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