Fatty Acids have contributory but Not Causal Relationship with Periodontitis: Study

Researchers have found in a new study that there was a significant associations between certain fatty acids and periodontitis, suggesting they may influence its severity. However, Mendelian randomization (MR) analyses did not support a direct causal relationship. Further findings of study emphasize the importance of a balanced dietary lipid profile in maintaining periodontal health.

The authors aimed to explore the association of fatty acids with periodontitis and its severity and to assess causality using Mendelian randomization (MR) analyses. Data for participants with complete data were extracted from the 2009-2014 National Health and Nutrition Examination Survey. Weighted logistic regression was used to explore the relationship between dietary fatty acids and periodontitis and its severity. Univariable and multivariable MR analyses were performed to explore the causal association between plasma fatty acids and periodontitis. Results: Two types of saturated fatty acids (hexadecanoic C16:0, octadecanoic C18:0) and monounsaturated fatty acids (hexadecenoic C16:1, docosenoic C22:1) and 3 types of polyunsaturated fatty acids (eicosatetraenoic C20:4, eicosapentaenoic C20:5, docosahexaenoic C22:6) were positively associated with periodontitis. Conversely, octadecadienoic (C18:2, a type of polyunsaturated fatty acid), total polyunsaturated fatty acids, and omega-6 fatty acids were negatively associated with periodontitis. Similar association patterns were also found between these fatty acids and the severity of periodontitis. Results of Mendelian randomization analyses revealed that no significant association was found between plasma fatty acids and periodontitis. The authors provided evidence of significant associations between certain fatty acids and periodontitis and its severity, highlighting their contributory role, although the evidence does not support a causal role based on the results of Mendelian randomization-based analyses. The results of this study support a contributory or inhibitory role of fatty acids in the progression of periodontitis, although not as a direct cause, and underscored the importance of maintaining a balanced dietary lipid profile for periodontal health.

Reference:

Association of dietary and plasma fatty acids with periodontitis. Xie, Bingqin et al. The Journal of the American Dental Association, Volume 156, Issue 3, 198 – 210.e28

Keywords:

Fatty Acids, contributory, Causal Relationship, Periodontitis, Study, The Journal of the American Dental Association, Fatty acids, periodontitis, NHANES Mendelian randomization analysis

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AI-powered model may predict prognosis and immunotherapy response in colorectal cancer patients: Study

By leveraging multi-omics analysis and machine learning techniques, the research team led by Professor Shuo Wang (Institute of Microbiology, the Chinese Academy of Sciences) developed an Immune Response-related Risk Score (IRRS) model to predict prognosis and immunotherapy response in colorectal cancer (CRC) patients. The study integrated clinical data and transcriptomic profiles from TCGA-CRC and six validation cohorts to identify a robust multi-gene signature.

Through machine learning-based feature selection, the team identified 13 core immune-related genes (IL18BP, RSAD2, G0S2, SIGLEC1, SFRP2, IFI44L, ISG20, IFIT1, OLR1, SAMHD1, HK3, PTAFR, CSF1) that play critical roles in the regulation of the tumor immune microenvironment and response to immunotherapy. The IRRS model, constructed using Random Survival Forest (RSF) and Lasso regression, was validated across multiple datasets and demonstrated superior predictive performance.

In the GSE91061, GSE78220, and IMvigor210 datasets, IRRS effectively stratified patients into high-risk and low-risk groups, with significant survival differences. The ROC analysis confirmed that IRRS outperformed TIDE in predicting immunotherapy response, with higher AUC values across all datasets. Notably, higher IRRS scores correlated with poorer survival and less immune activation, while low IRRS scores were associated with better prognosis and increased immune infiltration.

To further investigate the biological mechanisms underlying IRRS, the researchers conducted immune infiltration analysis and pathway enrichment studies. The results revealed that low-risk IRRS patients exhibited higher levels of immune cell infiltration, particularly CD8+ T cells and natural killer (NK) cells, suggesting an enhanced anti-tumor immune response. Additionally, epigenetic modifications, such as DNA methylation patterns, were analyzed, highlighting potential regulatory mechanisms affecting gene expression in high-risk versus low-risk patients.

“These findings demonstrate that immune-related molecular signatures can serve as reliable predictors of CRC prognosis and immunotherapy response,” said Dr. Wang. “The IRRS model provides a clinically relevant and superior alternative to existing predictive tools, paving the way for more personalized and effective immunotherapy strategies.”

While current scientific consensus suggests that traditional CRC risk models rely heavily on TNM staging, this study presents a paradigm shift by incorporating immune system dynamics into risk assessment. The findings underscore the importance of machine learning and multi-omics data integration in developing precision oncology tools for CRC management.

Future directions include expanding the IRRS model to other cancer types and refining its predictive power through multi-center clinical validation. The study sets the foundation for next-generation precision immunotherapy approaches, encouraging researchers to further explore immune signatures in cancer treatment. 

Reference:

Zhen Liu, Dou Yu, Pengyan Xia, Shuo Wang, Machine learning approach to predict prognosis and immunotherapy responses in colorectal cancer patients, hLife, https://doi.org/10.1016/j.hlife.2025.02.001.

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HC quashes criminal proceedings against doctor accused of medical negligence, hitting patient with motorcycle

Lucknow: Granting relief to a doctor who was first accused of medical negligence resulting in malignancy and then hitting the patient with a motorcycle, the Allahabad High Court recently quashed the criminal proceedings against him.

Apart from Dr. Srivastava, the HC bench comprising Justice Shree Prakash Singh also quashed the criminal proceedings against Advocate Ramesh Kumar Srivastava, as it held that the prosecution was instituted with mala fide and malicious intent.

“…the facts and circumstances of the present matter is indicative that the first information report has been lodged with a malafide and malicious intention,” observed the HC bench in its order dated April 10, 2025.

The case stems from a First Information Report (FIR) lodged on 8 February 2007 by a complainant who alleged that Dr. Srivastava had performed a negligent surgery at the Prathmik Swasthya Kendra, Malihabad, resulting in malignancy. Following this, when she was sitting on a dharna, both the doctor and the advocate had allegedly hit her with a motorcycle and threatened her with dire consequences. This led to a fracture in her left elbow, alleged the complainant. Ultimately, the complainant/patient died of cancer in 2009.

Based on the complaint, charges under Sections 325 and 506 IPC were framed based on the chargesheet dated 18 December 2007 and consequently, the Chief Judicial Magistrate, Lucknow, issued summoning orders on 19 December 2007 and 22 July 2013.

Also Read: HC quashes SC, ST Act, Negligence charges against MBBS doctor in gallbladder surgery death case

Challenging these proceedings, the doctor and the advocate approached the HC bench, and their counsel, Sanjay Kumar Srivastav, argued that the FIR was lodged after an unexplained delay of nearly two months. He also argued that the charge sheet was filed hurriedly without proper investigation and emphasized that the protection witnesses, including the complainant’s husband, were not eyewitnesses and relied solely on hearsay.

The applicants claimed that Dr. Srivastava was on emergency and Pulse Polio duty at P.H.C. Malihabad on the date of the alleged incident, and Ramesh Kumar Srivastava (another accused) was present at the High Court, where several of his cases were listed, supported by affidavits of four advocates.

It was further submitted that no evidence of medical negligence was found against Dr. Srivastava in an earlier departmental inquiry by Dr. M.K. Gupta, Deputy CMO, on 29.08.2006.

The doctor and the advocate, who were accused in the matter, further argued that the complaint was filed after the complainant failed to obtain compensation. They claimed that consequently, the complainant tried to falsely implicate them due to a personal grudge and failed extortion attempts.

On the other hand, the Additional Government Advocate submitted that the applicants were named in the FIR, and two rounds of investigations had been conducted. The initial investigation was done by the original Investigating Officer and then a second officer was appointed after the applicants applied for further investigation. The AGA submitted that the charge sheet and summoning orders were based on available evidence.

While considering the matter, the HC bench observed that Dr. Srivastava had been exonerated in the departmental inquiry, which had concluded that any medical negligence pertained to a private hospital, not the government facility.

“In so far as the present case is concerned, it is
prima-facie apparent that there being without any
cogent reason or evidence, the opposite party no.2
moved an application to the Chief Medical Officer with
the allegation that because of the operation conducted
by the applicant no. 2 (the doctor), she had suffered with
malignancy, though there is no medical report submitted in support of her complaint and when an
enquiry was conducted, it was found that the complaint
is false against the applicant no. 2 and thereafter, the
first information report has been lodged, while hatching
the applicants in a criminal conspiracy for personal
grudge.”

Further, the Court noted that when the complainant lodged the FIR on the incident dated 08.02.2007 while alleging the incident of 15.01.2007 even though “there is no explanation of the delay”.

Referring to the allegation that the applicants had hit the complainant with a motorcycle, leading to her fracture, the HC bench observed, “…having at glance the whole scenario, this is not understandable that for what reason and motive, the applicants would be intended to commit such offence.”

“It is also evident that the place where the incident is said to have occurred, is a public place, but there is no public eye witness of the incident, whereas, one of the witness namely, ****, who supported the version of the prosecution, is also not an ocular witness of the incident and he on the basis of receiving the information from the husband of the opposite party no. 2, has deposed before the police,” the bench further noted.

Regarding the claim by the applicants that Dr. Srivastava was on an emergency duty, from 14.01.2007 to 15.01.2007 and thereafter he was on Pulse Polio Duty, the Court noted that this fact had been certified by the Superintendent of P.H.C. Malihabad and “…this fact has not been denied anywhere in the Counter Affidavit filed on behalf of the State-respondent.”

At this outset, the Court also observed that the presence of Advocate Srivastava in the High Court on 15.01.2007 was supported by four other witnesses, “but, this fact seems to be ignored by the Investigating Officer as well as the learned trial court while issuing the summons. Further this fact has also not been denied by the State in it’s Counter Affidavit.”

The High Court bench referred to the Supreme Court’s order in the case State of Haryana vs. Bhajan Lal, and concluded that this case squarely fell under category (7) of mala fide prosecution.

“…the facts and circumstances of the present matter is indicative that the first information report has been lodged with a malafide and malicious intention, which is squarely covered with the ratio of the Judgment of the Hon’ble Apex Court in the case of Bhajan Lal(Supra),” observed the Court.

“It is trite law that it would not only be sufficient for the court to look into the averments made in the first information report/complaint alone to find out whether the necessary ingredients to constitute the alleged offence are disclosed, but, the court owes a duty to look into the other attending circumstances emerging from the record of the case over and above the averments and if it is required, the court with due care and caution, would try to read in between the lines. So far as the present case is concerned, the background of the circumstances indicates that the allegations levelled in the first information report, seem to be with a motive to wreaking vengeance and malafide,” it noted.

Accordingly, the Court quashed the criminal proceedings against the doctor and the advocate while noting that “the trial would result in a gross abuse of process of the law and would not serve the ends of justice.”

To view the order, click on the link below:

https://medicaldialogues.in/pdf_upload/allahabad-hc-quashes-criminal-proceedings-282636.pdf

Also Read: SC quashes Culpable Homicide Charges against Doctor for prescribing injection over phone

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Doctor assaulted after patient’s death, services halted at Dhanbad Hospital

An on-duty senior resident doctor at the government-run Shaheed Nirmal Mahato Medical College and Hospital (SNMMCH) in Jharkhand’s Dhanbad was allegedly assaulted by relatives of a young patient who passed away while undergoing treatment for a snakebite at the hospital.

Medical services at the hospital were severely hit for over eight hours on Thursday as doctors went on a strike after a senior resident doctor was assaulted by relatives of a deceased patient, officials said.

For more information, click on the link below:

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IGIMS Patna medico dies, protests erupt over alleged bed denial

Medicos at Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, are protesting over the death of a fellow MBBS student, who allegedly did not get a bed at the institute after being injured in a road accident.

On April 7, the student was initially brought to the IGIMS after he got injured in the accident. However, he was not admitted to the hospital, citing lack of beds. Thereafter, he was taken to a private hospital, where he died during treatment.

For more information, click on the link below:

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Rajasthan: Doctors from 13 specialities struggle to get jobs in Govt Hospitals

Despite completing their postgraduate degrees, the doctors in 13 different specialities in Rajasthan are unable to contribute to the State public health sector as the Rajasthan Government has not created any posts of junior specialists, senior specialists, and principal specialities in those specialities in its hospitals.

These specialties include biochemistry, radiation oncology, transfusion medicine, preventive and social medicine, emergency medicine, physical medicine and rehabilitation, palliative medicine, anatomy, physiology, pharmacology, nuclear medicine, family medicine, and hospital administration.

For more information, click on the link below:

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Aurobindo Pharma arm gets 11 USFDA observations for Raleigh Plant

Hyderabad: Aurobindo Pharma has announced that the United States Food and Drug Administration (USFDA) has issued 11 observations after an inspection at Raleigh Plant, North Carolina, USA, owned by Aurolife Pharma LLC, a wholly owned step-down subsidiary of the Company, established for manufacturing Inhalers and Derma products.

The inspection was conducted from March 24, 2025 to April 10, 2025.

As per the Company, the inspection was completed on April 10, 2025 and at the conclusion, the USFDA issued a Form 483 with
11 observations. 

An FDA Form 483 is issued to firm management at the conclusion of an inspection when an investigator(s) has observed any conditions that in their judgment may constitute violations of the Food Drug and Cosmetic (FD&C) Act and related Acts.

“These observations are procedural in nature.
We will submit a comprehensive response to the USFDA within the stipulated timeline, addressing each
observation with appropriate corrective and preventive actions. The Company is committed to maintaining
the highest standards of quality and compliance across all its operations.
We do not expect this development to have any material impact on the current business operations or
existing supplies from this facility,” Aurobindo stated in a BSE filing.

Read also: Aurobindo Pharma arm CuraTeQ Biologics completes successful Phase 1 Pharmacokinetics study of bone drug

Aurobindo Pharma Limited is an integrated global pharmaceutical company headquartered in Hyderabad, India. The Company develops, manufactures, and commercializes a wide range of generic pharmaceuticals, branded specialty pharmaceuticals and active pharmaceutical ingredients globally in over 150 countries.

The company has 29 manufacturing and packaging facilities that are approved by regulatory agencies including USFDA, UK MHRA, EDQM, Japan PMDA, WHO, Health Canada, South Africa MCC, Brazil ANVISA. The Company’s product portfolio is spread over seven major therapeutic/product areas encompassing CNS, Anti-Retroviral, CVS, Antibiotics, Gastroenterological, Anti-Diabetics and Anti-Allergic.

Read also: Aurobindo Pharma arm gets European Commission authorization to market Dyrupeg in EU

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HC scraps Rs 30 lakh seat-leaving penalty, directs medical college to return documents

Granting relief to a doctor who had to leave his postgraduate studies midway after the violence erupted in Manipur, the Madhya Pradesh High Court has directed Bundelkhand Medical College to return the original documents to him within 7 days.

Hailing from Imphal, the doctor cleared the National Eligibility-Entrance Test Postgraduate (NEET-PG) exam in 2021 and was admitted to an MD degree course at Bundelkhand Medical College, which is located approximately 170 km away from Bhopal.

For more information, click on the link below:

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Health Bulletin 11/ April/ 2025

Here are the top health news for the day:

HC scraps Rs 30 lakh seat-leaving penalty, directs medical college to return documents

Granting relief to a doctor who had to leave his postgraduate studies midway after the violence erupted in Manipur, the Madhya Pradesh High Court has directed Bundelkhand Medical College to return the original documents to him within 7 days.

Hailing from Imphal, the doctor cleared the National Eligibility-Entrance Test Postgraduate (NEET-PG) exam in 2021 and was admitted to an MD degree course at Bundelkhand Medical College, which is located approximately 170 km away from Bhopal.

For more information, click on the link below:
Rajasthan: Doctors from 13 specialities struggle to get jobs in Govt Hospitals

Despite completing their postgraduate degrees, the doctors in 13 different specialities in Rajasthan are unable to contribute to the State public health sector as the Rajasthan Government has not created any posts of junior specialists, senior specialists, and principal specialities in those specialities in its hospitals.

These specialties include biochemistry, radiation oncology, transfusion medicine, preventive and social medicine, emergency medicine, physical medicine and rehabilitation, palliative medicine, anatomy, physiology, pharmacology, nuclear medicine, family medicine, and hospital administration.

For more information, click on the link below:

IGIMS Patna medico dies, protests erupt over alleged bed denial
Medicos at Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, are protesting over the death of a fellow MBBS student, who allegedly did not get a bed at the institute after being injured in a road accident.

On April 7, the student was initially brought to the IGIMS after he got injured in the accident. However, he was not admitted to the hospital, citing lack of beds. Thereafter, he was taken to a private hospital, where he died during treatment.

For more information, click on the link below:

Doctor assaulted after patient’s death, services halted at Dhanbad Hospital

An on-duty senior resident doctor at the government-run Shaheed Nirmal Mahato Medical College and Hospital (SNMMCH) in Jharkhand’s Dhanbad was allegedly assaulted by relatives of a young patient who passed away while undergoing treatment for a snakebite at the hospital.

Medical services at the hospital were severely hit for over eight hours on Thursday as doctors went on a strike after a senior resident doctor was assaulted by relatives of a deceased patient, officials said.

For more information, click on the link below:

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Increase in alcohol deaths in England an ‘acute crisis,’ say researchers

The persistent higher rate of alcohol deaths in England since the pandemic in 2020 is an “acute crisis” requiring urgent action from the government, according to a new study led by researchers at UCL and the University of Sheffield.

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