Surface protein study highlights a potential link between dental caries and renal lesions

IgA nephropathy (IgAN) is an immune response disease affecting the filtering units of the kidneys. It is an intractable disease with a complex physiological process. Streptococcus mutans, a dental caries-causing bacterial pathogen, has been linked to IgAN disease progression. Now, researchers from the Okayama University, Japan, have uncovered a virulent role of Cnm—a surface collagen-binding protein expressed on S. mutans in IgAN development—highlighting a potential link between dental caries and renal lesions.

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