E-cigarette use may significantly increase risk of uveitis, suggests study

A new study published in the journal of Ophthalmology showed that e-cigarette users have a significantly increased chance of getting uveitis when compared to non-users. Uveitis and other inflammatory conditions are linked to tobacco cigarettes and their contents. Over the past decade, the use of electronic cigarettes has increased, and numerous negative effects on eye health have been identified, including disturbances in tear film, choroidal blood flow, and ocular saccadic rhythms.

Studies have found that sputum of e-cigarette users contains higher amounts of proteins linked to oxidative stress. The individuals who vape nicotine may be at a higher risk of getting uveitis since these proteins have been connected to the start of the illness. Thus, Alan Hsu and colleagues looked into the possible correlation if this patient group did in fact have a higher chance of developing uveitis.

The patients over 18 years old with and without a recent history of e-cigarette use, were included from the TriNetX database. A total of 4,19,325 e-cigarette users and 4,19,325 comparators were included in their study. The racial distributions of the two groups were comparable, with patients of Asian, Black, or African, and white races among them. The incidence of newly identified uveitis was the main outcome.

With a hazard ratio (HR) of 2.53, the findings indicated that e-cigarette users had a higher chance of getting uveitis than non-users. According to age stratification in subgroup analyses, e-cigarette users who were between the ages of 18 and 39 (HR: 2.59), 40 and 64 (HR: 2.20), and 65 and older (HR: 3.15) had an increased risk of developing uveitis. Further, this risk remained constant throughout the course of the 4-year follow-up, suggesting that e-cigarette usage had both a short-term and long-term impact on the risk of uveitis. Despite not much e-cigarette usage, traditional cigarette smoking was also found to raise the risk of uveitis. Also, the individuals who had a history of using both e-cigarettes and traditional cigarettes were at a greater risk of developing uveitis when compared to individuals who only used conventional cigarettes.

Overall, the results from this study merit more research, particularly because there has only been case reports linking e-cigarette usage to uveitis in the past. This study demonstrated that medical professionals should be mindful of the possible elevated risk of developing uveitis in individuals with a history of e-cigarette use.

Reference:

Hsu, A. Y., Wang, Y.-H., Hsia, N.-Y., Lai, C.-T., Kuo, H.-T., Wu, B.-Q., Lin, C.-J., Chiang, C.-C., Shao, Y.-C., Chen, H.-S., Tsai, Y.-Y., & Wei, J. C.-C. (2024). Risk of uveitis among E-Cigarette Users: a multi-institutional TriNetX study. In Ophthalmology. Elsevier BV. https://doi.org/10.1016/j.ophtha.2024.11.008

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Laparoscopic Surgery Non-Inferior to Open Surgery for Low Rectal Cancer, reports research

Researchers have discovered that laparoscopic surgery is non-inferior to open surgery regarding 3-year disease-free survival for the treatment of low rectal cancer. A recent study was conducted by Jiang W. and colleagues published in The Lancet journal.

Low rectal cancer is a challenging disease to treat because of its anatomical location and high risk of recurrence. Although laparoscopic surgery reduces recovery time and postoperative pain, the long-term oncologic outcome has been a controversy, especially in cases of low rectal cancer. This study compared 3-year disease-free survival and overall survival of laparoscopic versus open surgery for low rectal cancer.

The study included 1,070 patients aged 18–75 years with histologically confirmed low rectal adenocarcinoma within 5 cm from the dentate line. Patients were randomly assigned in a 2:1 ratio to either laparoscopic surgery (685 patients) or open surgery (354 patients). Participants were stratified according to the clinical stage, age, sex, BMI, and ASA classification. The main outcome measure of interest was 3-year disease-free survival, defined as locoregional recurrence, distant metastasis, or death.

Key findings of the study were as follows:

3-Year Disease-Free Survival:

  • Laparoscopic surgery: 81.4% (95% CI 78.2 to 84.1).

  • Open surgery: 79.8% (95% CI 75.2 to 83.6).

  • HR: 0.92 (95% CI 0.69 to 1.23; p = 0.56).

  • Non-inferiority margin met with a difference of 1.60% (97.5% CI -3.34 to ∞).

3-Year Overall Survival:

  • Laparoscopic surgery: 91.7% (95% CI 89.3 to 93.5).

  • Open surgery: 93.7% (95% CI 90.6 to 95.8).

  • HR: 1.34 (95% CI 0.82 to 2.19; p = 0.24).

3-Year Locoregional Recurrence:

  • Laparoscopic surgery: 3.7% (95% CI 2.5 to 5.3).

  • Open surgery: 2.3% (95% CI 1.1 to 4.3).

  • HR: 1.64 (95% CI 0.74 to 3.63; p = 0.22).

5-Year Overall Survival:

  • Laparoscopic surgery: 84.6% (95% CI 81.5 to 87.1).

  • Open surgery: 86.6% (95% CI 82.5 to 89.8).

  • HR: 1.16 (95% CI 0.82 to 1.64; p = 0.41).

This multicenter trial confirms that laparoscopic surgery is non-inferior to open surgery for 3-year disease-free survival in patients with low rectal cancer. These findings provide strong evidence that supports laparoscopic surgery as the effective and minimally invasive alternative to open surgery for low rectal cancer.

Reference:

Jiang, W., Xu, J., Cui, M., Qiu, H., Wang, Z., Kang, L., Deng, H., Chen, W., Zhang, Q., Du, X., Yang, C., Guo, Y., Zhong, M., Ye, K., You, J., Xu, D., Li, X., Xiong, Z., Tao, K., … LASRE trial investigators. (2024). Laparoscopy-assisted versus open surgery for low rectal cancer (LASRE): 3-year survival outcomes of a multicentre, randomised, controlled, non-inferiority trial. The Lancet. Gastroenterology & Hepatology. https://doi.org/10.1016/S2468-1253(24)00273-5

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COVID-19 infection not tied to worsening symptoms among MS patients: Study

For people with multiple sclerosis (MS), having a COVID-19 infection is not associated with worsening MS symptoms or disability, according to a study published in the December 23, 2024, online issue of Neurology®, the medical journal of the American Academy of Neurology.

“Infections may be associated with more disability among people with MS,” said study author Amber Salter, PhD, of UT Southwestern Medical Center in Dallas, Texas, and a member of the American Academy of Neurology. “However, our study found that for COVID-19 infections specifically, this was not true. This is good news for people with MS, that they do not need to worry about long-term worsening of their MS symptoms after a COVID-19 infection.”

The study involved 2,132 adults with MS with an average age of 65. They were followed over 18 months.

Participants completed a questionnaire, reporting whether they ever had a COVID-19 infection that was confirmed by a test.

A total of 796 people reported having a COVID-19 infection and 1,336 people reported never having COVID-19.

Participants also reported the severity of their MS symptoms at least six times during the study. They were asked about walking, hand function, bodily pain, fatigue and memory and thinking. They were scored based on symptom severity.

Participants also reported their level of disability based on how their condition affects daily activities like walking or standing.

After adjusting for factors such as age, race and gender, researchers found that for both those with COVID-19 infection and those without, MS symptom severity increased nominally by 0.02 points per month, both before and after a COVID-19 infection. They found no difference in MS symptom severity between those with COVID-19 infection and those without.

For disability, researchers found similar results.

“Our study indicates that COVID-19 infection was not associated with immediate changes in symptom severity or disability, nor did it change the MS symptoms or disability trajectory for more than a year and a half after the infection,” said Salter. “While our study looked primarily at older people and results may not be the same for younger people, these findings help us better understand how this type of infection can affect people with MS.”

A limitation of the study was that tests for COVID-19 infection can produce incorrect results, so not everyone who had COVID-19 may have tested positive. Also, people may have had COVID-19 and did not know it.

Reference:

Amber Salter, Effects of COVID-19 Infection on Symptom Severity and Disability in Multiple Sclerosis, Neurology, https://doi.org/10.1212/WNL.0000000000210149

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Serum Podoplanin Levels Potential Biomarker for Diabetic Nephropathy Progression: Study

Lower levels of serum Podoplanin may predict diabetic nephropathy among diabetes patients suggests a study published in the Diabetes Metabolic Syndrome.

The study aimed to investigate the impact of serum Podoplanin levels on diabetic nephropathy in patients with type 2 diabetes mellitus (T2DM). Patients and methods: Between January 2022 and December 2023, the Department of Nephrology at Nantong Second People’s Hospital selected 276 patients with T2DM and 150 healthy controls for this investigation. Systematic data collection was performed to gather information on biomarkers and biochemical parameters. Results: When T2DM patients (n=276) and healthy controls (n=150) were compared, considerably lowered serum Podoplanin levels were observed. In all 276 patients, serum Podoplanin levels were negatively associated with age (r=− 0.127, P=0.035), body mass index (BMI) (r=− 0.292, P< 0.001), duration of diabetes (r=− 0.323, P< 0.001), systolic blood pressure (SBP) (r=− 0.255, P< 0.001), diastolic blood pressure (DBP) (r=− 0.138, P=0.022), fasting blood glucose (FBG) (r=− 0.196, P=0.001), glycated hemoglobin (HbA1c) (r=− 0.095, P=0.117), triglyceride (TG) (r=− 0.157, P=0.009), total cholesterol (TC) (r=− 0.126, P=0.036), low-density lipoprotein cholesterol (LDL-C) (r=− 0.187, P=0.002), serum creatinine (Scr) (r=− 0.500, P< 0.001), neutrophil gelatinase-associated lipocalin (NGAL) (r=− 0.339, P< 0.001), and kidney injury molecule-1 (KIM-1) (r=− 0.568, P< 0.001), and was positively correlated with high-density lipoprotein cholesterol (HDL-C) (r=0.343, P< 0.001) and estimated glomerular filtration rate (eGFR) (r=0.442, P< 0.001). The multivariate logistic regression analysis showed that diabetic patients with DN had lowered levels of serum Podoplanin (OR=0.022, 95% CI=0.005– 0.100; P< 0.001), lower SBP, Scr, NGAL, and KIM-1. The results indicated that diabetic patients with DN have lower levels of serum Podoplanin. A more considerable population-based prospective investigation is essential to validate our findings.

Reference:

Huan F, Jiang X. Serum Podoplanin Levels as a Potential Biomarker for Diabetic Nephropathy Progression: A Cross-Sectional Study. Diabetes Metab Syndr Obes. 2024;17:4701-4710

https://doi.org/10.2147/DMSO.S500608

Keywords:

Lower, levels, serum, Podoplanin, may, predict, diabetic, nephropathy, among, diabetes, patients, study, podoplanin, type 2 diabetes mellitus, diabetic nephropathy, biomarker, Huan F, Jiang X, Diabetes Metabolic Syndrome

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Can drinking coffee or tea help prevent head and neck cancer?

In a recent analysis of data from more than a dozen studies, coffee and tea consumption was linked with lower risks of developing head and neck cancer, including cancers of the mouth and throat. The findings are published by Wiley online in CANCER, a peer-reviewed journal of theAmerican Cancer Society.

Head and neck cancer is the seventh most common cancer worldwide, and rates are rising in low- and middle-income countries. Many studies have assessed whether drinking coffee or tea is associated with head and neck cancer, with inconsistent results.

To provide additional insight, investigators examined data from 14 studies by different scientists associated with the International Head and Neck Cancer Epidemiology consortium, a collaboration of research groups around the globe. Study participants completed questionnaires about their prior consumption of caffeinated coffee, decaffeinated coffee, and tea in cups per day/week/month/year.

When investigators pooled information on 9,548 patients with head and neck cancer and 15,783 controls without cancer, they found that compared with non-coffee-drinkers, individuals who drank more than 4 cups of caffeinated coffee daily had 17% lower odds of having head and neck cancer overall, 30% lower odds of having cancer of the oral cavity, and 22% lower odds of having throat cancer. Drinking 3-4 cups of caffeinated coffee was linked with a 41% lower risk of having hypopharyngeal cancer (a type of cancer at the bottom of the throat).

Drinking decaffeinated coffee was associated with 25% lower odds of oral cavity cancer. Drinking tea was linked with 29% lower odds of hypopharyngeal cancer. Also, drinking 1 cup or less of tea daily was linked with a 9% lower risk of head and neck cancer overall and a 27% lower risk of hypopharyngeal cancer, but drinking more than 1 cup was associated with 38% higher odds of laryngeal cancer.

“While there has been prior research on coffee and tea consumption and reduced risk of cancer, this study highlighted their varying effects with different sub-sites of head and neck cancer, including the observation that even decaffeinated coffee had some positive impact,” said senior author Yuan-Chin Amy Lee, PhD, of Huntsman Cancer Institute and the University of Utah School of Medicine. “Coffee and tea habits are fairly complex, and these findings support the need for more data and further studies around the impact that coffee and tea can have on reducing cancer risk.”

Reference:

Timothy Nguyen, Alzina Koric, Chun-Pin Esther Chang, Christine Barul, Loredana Radoi, Coffee and tea consumption and the risk of head and neck cancer: An updated pooled analysis in the International Head and Neck Cancer Epidemiology Consortium, Cancer, https://doi.org/10.1002/cncr.35620

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Women with early bilateral oophorectomy at high risk of Alzheimer’s Disease, reports research

A new study published in the Journal of Alzheimer’s Disease showed that Alzheimer disease risk is increased by early bilateral oophorectomy (BO). By 2050, it is anticipated that 12.7 million people 65 and older would have Alzheimer’s disease (AD). Two-thirds of the individuals with AD are female. Therefore, reducing the number of people who acquire AD requires an awareness of the unique risk and resilience variables associated with AD in women.

The decrease of 17β-estradiol (E2) during menopause is a significant sex-related component. A few studies have examined women’s risk for dementia from all causes using the UK Biobank, a prospective population-based database of over 500,000 people with comprehensive phenotypic and genetic data. However, the findings involving menopause are conflicting. In fact, there is currently ample evidence linking early BO to a higher risk of dementia and/or cognitive impairment.In order to compare the odds ratios of AD to those of women who experienced spontaneous menopause (SM), this study looked at the prevalence and determinants of AD in women with early BO.

Women with early BO or SM who were 60 years of age or older at baseline, with or without AD, were included in a UK Biobank cohort (n = 34,603). The ICD-10 or ICD-9 code associated with AD was used to determine AD. To model the relationship between menopausal type and AD, this study employed logistic regression. Age, education, menopausal age, hormone treatment (HT), APOE4, body mass index (BMI), history of cancer, and history of smoking were all model variables.

The odds of developing AD were 4-times higher for individuals with early BO than for those with SM. In the BO group, older age and APOE4 were linked to higher risks of AD. While ever using HT was linked to lower odds of AD exclusively for the BO group, more years of schooling were linked to lower risks of AD for both BO and SM.

Overall, the probabilities of AD in women with early BO were determined by this investigation. The probabilities of AD were significantly raised by early BO itself. In addition, among women with early BO, possessing one or more APOE4 allele was substantially associated with higher risks of AD. Higher BMI, more education, and ever using HT were linked to lower risks.

Reference:

Calvo, N., McFall, G. P., Ramana, S., Galper, M., Fuller-Thomson, E., Dixon, R. A., & Einstein, G. (2024). Associated risk and resilience factors of Alzheimer’s disease in women with early bilateral oophorectomy: Data from the UK Biobank. In Journal of Alzheimer’s Disease (Vol. 102, Issue 1, pp. 119–128). SAGE Publications. https://doi.org/10.3233/jad-240646

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Incorporating Arginine in fancy water beverages lowers erosive tooth wear potential of these beverages: Study

Researchers have reported that the addition of arginine (Arg) in flavored fancy waters significantly lowers their potential to cause erosive tooth wear. Erosive tooth wear is a progressive loss of enamel caused by acidic beverages, commonly seen among young people. A recent study was conducted by Mohammed N. and colleagues published in the Journal of Dentistry.

With the increased popularity of flavored sparkling and carbonated beverages, erosive wear is an important issue. The oral health benefits of L-arginine have been reported in various studies. In this study, the efficacy of five commercially available fancy waters containing L-arginine was tested in reducing tooth wear over a controlled period of 72 hours.

The five commercial fancy waters, Oasis Lemon, Oasis Lemon Mint, Perrier Lemon, Perrier Grapefruit, and Pellegrino Lemon, were enriched with 2% L-arginine (w/v). Deionized water was used as a negative control. Key parameters, such as pH, buffer capacity, and fluoride (F−) concentrations, were measured to determine the impact of arginine addition.

To prepare, specimens were subjected to baseline volumetric analysis using micro-CT imaging. The specimens were then placed in the beverages for 72 hours at 37°C, with solutions changed every 24 hours. Post-exposure, 3D volumetric assessments and structural reconstructions were conducted to quantify and visualize enamel wear.

Key Findings

Improved pH and Fluoride Concentrations::

  • Fancy waters with arginine had significantly higher pH and fluoride concentration compared to the control (p < 0.001).

Buffer Capacity:

  • Among the arginine-rich drinks, Perrier-Grapefruit had the highest buffer capacity, which was significantly higher than Oasis Lemon, Oasis Lemon Mint, and Pellegrino Lemon (p < 0.05).

Enamel Volume Retention:

  • The specimens treated with Oasis Lemon Mint (± arginine) and Pellegrino Lemon (control) showed significant volume loss compared to baseline (p < 0.05).

  • Arginine-containing drinks had higher specimen volume compared to the non-arginine counterparts, thus proving their protective role.

Surface Wear Evidence:

  • Surface contrast imaging showed evident wear from baseline (T0) to the final analysis (T1) in specimens treated with Oasis Lemon Mint (± arginine) and Pellegrino Lemon without arginine.

Arginine enrichment of flavored fancy waters may minimize their erosive potential. This may provide a preventive mechanism against enamel wear and tear. The current research findings suggest that the formulation of beverages should be addressed to meet oral health needs without compromising consumer appeal. This would help reduce the burden of dental erosion among at-risk populations by promoting arginine-enriched beverages.

Reference:

Bijle, Mohammed Nadeem & Sharaf, Dalya & BAHDAR, Moussa & Daood, Umer & Yiu, Cynthia. (2024). Preventive potential of arginine incorporated in fancy waters for erosive tooth wear. Journal of Dentistry. 153. 10.1016/j.jdent.2024.105500.

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New clinical practice guideline on process for diagnosing Alzheimer’s disease or related form of cognitive impairment or dementia

We have entered a new era of improved and emerging biologically-based diagnostic biomarkers for Alzheimer’s disease (AD) and AD-related neurodegenerative disorders (ADRD) that are rapidly impacting evaluation and care paradigms in every clinical setting: primary care, specialty care and dementia subspecialty care.

A comprehensive evaluation includes setting goals in partnership with the patient and usually a care partner; obtaining information about the patient’s risk profile for AD or a related disease (e.g., age, family history of dementia, hypertension, smoking); describing the history of symptoms and their impact on daily life; evaluating the patient’s ability to perform tests of thinking abilities; and obtaining a brain MRI or CT scan along with laboratory tests for conditions that may contribute to cognitive impairment. The integration of new brain scans, spinal fluid tests, or other specialized tests into this comprehensive evaluation will add critical value to the diagnostic formulation and care plan for persons in whom there is a clinical concern for AD or an ADRD.

A special issue of the journal Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association highlights the new Alzheimer’s Association Clinical Practice Guideline for the Diagnostic Evaluation, Testing, Counseling and Disclosure of Suspected Alzheimer’s Disease and Related Disorders (DETeCD-ADRD CPG) that summarizes the process of diagnostic evaluation and disclosure for persons suspected of potentially having cognitive-behavioral impairment due to AD or ADRD. ADRDs include Lewy Body Disease, Frontotemporal Lobar Degeneration, Vascular Cognitive Impairment and Dementia (VCID), and a host of other diseases and conditions that may cause or substantially contribute to cognitive-behavioral impairment. Similar American guidelines are more than 20 years old and aimed at specialists or dementia subspecialists.

“With this guideline, we expand the scope of prior guidelines by providing recommendations for practicing clinicians on the process from start to finish,” said Brad Dickerson, M.D., Director of the Massachusetts General Hospital Frontotemporal Disorders Unit and Professor of Neurology at Harvard Medical School. “We recommend that medical professionals begin by making sure their thinking about the goals of the evaluation aligns with that of the patient, which usually requires a discussion to educate the patient on the specific steps of the process. Then we outline the steps involved in obtaining information about symptoms and examination, followed by a variety of diagnostic tests tailored to the patient, and summarize best practices regarding the diagnostic disclosure process.”

“We emphasize the importance of the involvement of a care partner throughout this process for most patients, since cognitive symptoms often compromise a person’s ability to process all of this information by themselves,” Dickerson added.

This guideline does not propose diagnostic or staging criteria for these diseases, which continue to evolve. Rather, it provides a framework for a high-quality process tailored to each individual patient that enables clinicians to establish a three-step diagnostic formulation including:

  • Cognitive Functional Status-the overall level of impairment, such as mild cognitive impairment or dementia.
  • Cognitive-Behavioral Syndrome- the symptoms the person is experiencing (e.g., progressive language difficulty and memory loss with depression).
  • The likely brain disease(s) or condition(s) causing the symptoms.

“The workgroup provides rigorous, evidence- and practice-informed foundational steps that capture the core elements of a high-quality evaluation and disclosure process,” Dickerson said. “The guidelines are formulated into 19 practical recommendations that are applicable to any practice setting, including primary care, along with additional guidance for specialists and subspecialists.”

In this special issue of Alzheimer’s & Dementia, the three executive summaries* by the DETeCD-ADRD CPG workgroup distill these recommendations, briefly summarize the evidence supporting them, and operationalize them as a series of steps in an evaluation process. A comprehensive report hosted online provides extensive details about the guideline development methodology, evidence review process, peer review process, rationale and recommendations for implementation, and specific narratives with evidence supporting each recommendation.

“The AD/ADRD field has entered a new era and is moving rapidly, which is very exciting,” said Alireza Atri, M.D., Ph.D., Chief Medical Officer, Banner Research, and Director of the Banner Sun Health Research Institute, Banner Health, Sun City and Phoenix, Arizona, and Lecturer on Neurology, Brigham and Women’s Hospital and Harvard Medical School. “This first U.S. interdisciplinary national evaluation guideline, designed for broad clinical settings, provides a comprehensive foundation summarizing a high-quality and personalized process within which specific tests are slotted and can be updated as the field evolves.”

“Some details of the guideline will likely require modification as new tools and biomarkers become sufficiently validated for appropriate clinical use in real-world practice. The workgroup leveraged best evidence and practices to empower persons with memory or thinking symptoms or concerns and their loved ones, clinicians, and health systems, to engage in a person-centered process that will enhance knowledge, appreciation and autonomy for the person with a potential illness — and facilitate doing what is right for them,” Atri said.

The DETeCD-ADRD CPG workgroup includes experts from multiple disciplines and multiple care settings, including primary care and specialty care. The guideline concludes that if clinicians use the recommendations in this guideline and health care systems provide adequate resources, outcomes should improve in most patients in most practice settings.

“We encourage clinicians to review these guidelines and incorporate them into their practice,” said Maria C. Carrillo, Ph.D., Alzheimer’s Association chief science officer and medical affairs lead. “These guidelines are important because they guide clinicians in the evaluation of memory complaints, which could have many underlying causes. That is the necessary start for an early and accurate Alzheimer’s diagnosis. In addition, these guidelines provide clinicians information about other underlying causes that may contribute to the memory complaints.”

Reference:

The Alzheimer’s Association Clinical Practice Guideline for the Diagnostic Evaluation, Testing, Counseling and Disclosure of Suspected Alzheimer’s Disease and Related Disorders (DETeCD-ADRD): Executive Summary of Recommendations for Primary Care,” Atri, et al. https://doi.org/10.1002/alz.14333

“The Alzheimer’s Association Clinical Practice Guideline for the Diagnostic Evaluation, Testing, Counseling and Disclosure of Suspected Alzheimer’s Disease and Related Disorders (DETeCD-ADRD): Executive Summary of Recommendations for Specialty Care,” Dickerson, et al. https://doi.org/10.1002/alz.14337

“The Alzheimer’s Association Clinical Practice Guideline for the Diagnostic Evaluation, Testing, Counseling and Disclosure of Suspected Alzheimer’s Disease and Related Disorders (DETeCD-ADRD): Validated Clinical Assessment Instruments,” Atri, et al. https://doi.org/10.1002/alz.14335

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Acetabular Dysplasia Linked to Increased Risk of Hip Osteoarthritis in Women and Older Adults: Research Suggests

Netherlands: A meta-analysis of data from over 18,000 hips revealed that acetabular dysplasia (AD) significantly raises the risk of developing radiographic hip osteoarthritis (RHOA) over a 4-8-year period. Hips with AD exhibited 1.8 times greater odds of progressing to RHOA compared to non-AD hips. The risk was notably higher among women, individuals aged 61-70, and those with a BMI under 25.

The findings, published in the journal Osteoarthritis and Cartilage, highlight the importance of monitoring individuals with AD for potential progression to osteoarthritis to enable early intervention and management.

Hip osteoarthritis (OA) has no curative nonsurgical treatment, making prevention vital. However, understanding risk factors for radiographic hip OA (RHOA) remains limited. Subtle hip shape abnormalities, such as acetabular dysplasia, may precede OA development and represent potential targets for prevention. AD, characterized by insufficient coverage of the femoral head by the acetabulum, leads to mechanical cartilage stress and may contribute to OA progression. Previous studies suggest an association between AD and RHOA, but inconsistencies and limited statistical power have hindered conclusive evidence.

Against the above background, Noortje S. Riedstra, Erasmus Medical Center, the Netherlands, and colleagues aimed to explore the relationship between various radiographic definitions of AD and incident RHOA, including subgroup analyses.

For this purpose, the researchers selected hips free of RHOA at baseline with a follow-up period of 4–8 years from the World COACH consortium. They calculated the Wiberg center edge angle (WCEA), acetabular depth width ratio (ADR), and modified acetabular index (mAI) to assess acetabular dysplasia. AD was defined as WCEA ≤ 25°, with secondary analyses using thresholds such as WCEA ≤ 20°, ADR ≤ 250, mAI ≥ 13°, and their combinations.

A logistic regression model with generalized mixed effects (3 levels) was applied, adjusting for age, biological sex, and body mass index (BMI). Descriptive statistics were reported stratified by age, sex, and BMI.

Key Findings:

  • The analysis included a total of 18,807 hips from 9 studies. Baseline characteristics included an average age of 61.84 years (± 8.32), a mean BMI of 27.40 kg/m² (± 4.49), and 70.1% of women.
  • Of the hips studied, 4766 hips (25.3%) had WCEA ≤ 25°.
  • During a follow-up period of 4–8 years (mean 5.8 ± 1.6), 378 hips (2.0%) developed incident RHOA.
  • There was an association between acetabular dysplasia and the development of RHOA (adjusted OR [aOR] 1.80).
  • Secondary analyses confirmed that all other definitions of AD were also associated with incident RHOA, with aOR values ranging from 1.52 to 1.96.
  • Descriptive statistics indicated a higher relative risk (RR) of developing RHOA in AD hips compared to non-AD hips in the following groups:
    • Age group 61–70 (RR 1.70)
    • BMI < 25 (RR 1.66)
    • Female hips (RR 1.73)

“Our study confirmed that acetabular dysplasia is a significant risk factor for the development of incident radiographic hip osteoarthritis (RHOA) in hips free of RHOA at baseline. Through an individual participant data (IPD) meta-analysis with large sample size, uniform AD measurements across radiographs, and a standardized RHOA outcome, the study provided a robust evaluation of the AD-RHOA association,” the authors wrote.

They emphasized that identifying modifiable risk factors like AD is critical for preventing hip osteoarthritis, improving quality of life, and advancing individualized care and the development of targeted treatments in the future.

Reference:

Riedstra NS, Boel F, van Buuren MMA, Ahedi H, Arbabi V, Arden N, Baart S, Bierma-Zeinstra S, Cicuttini F, Cootes TF, Crossley KM, Felson D, Giellis WP, Heerey J, Jones G, Kluzek S, Lane NE, Lindner C, Lynch JA, van Meurs JBJ, Mosler A, Nelson AE, Nevitt M, Oei E, Runhaar J, Tang J, Weinans H, Agricola R. Acetabular dysplasia and the risk of developing hip osteoarthritis within 4-8 years; an individual participant data meta-analysis of 18,807 hips from the World COACH consortium. Osteoarthritis Cartilage. 2024 Dec 8:S1063-4584(24)01479-1. doi: 10.1016/j.joca.2024.12.001. Epub ahead of print. PMID: 39657871.

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Pregnancy Vitamin D Supplementation Linked to Better Bone Health in Children: Study Finds

UK: A recent randomized controlled trial has highlighted the potential benefits of vitamin D supplementation during pregnancy, showing its positive impact on offspring bone health in mid-childhood. The findings suggest that mothers taking cholecalciferol (1000 IU/day) during pregnancy had children with higher bone mineral density (BMD) and greater lean mass compared to those whose mothers received a placebo.

The findings from the exploratory post-hoc analysis, published in The American Journal of Clinical Nutrition, indicate a clear association between maternal cholecalciferol use and improved bone health outcomes in their children.

Bone mineral density is a key marker of bone strength and overall skeletal health, and the research suggests that sufficient vitamin D during pregnancy could serve as a public health strategy to combat childhood bone-related disorders. Vitamin D plays a vital role in calcium absorption, which is critical for developing strong and healthy bones.

The Maternal Vitamin D Osteoporosis Study (MAVIDOS) trial provided evidence that gestational cholecalciferol supplementation positively influenced offspring bone mineral density (BMD) at age 4. Establishing whether this effect persists into later childhood is essential to determine if maternal vitamin D supplementation could be an effective public health strategy for improving long-term bone health. To this end, Rebecca J Moon, MRC Lifecourse Epidemiology Centre, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, United Kingdom, and colleagues explored whether gestational vitamin D supplementation leads to increased offspring BMD at ages 6–7 years through a post-hoc analysis of data from the existing trial.

In the MAVIDOS randomized controlled trial, pregnant women under 14 weeks of gestation with singleton pregnancies and serum 25-hydroxyvitamin D levels between 25–100 nmol/L at three UK hospitals (Southampton, Sheffield, and Oxford) were randomly assigned to receive either 1000 IU/day cholecalciferol or a placebo. This supplementation began between 14 and 17 weeks of gestation and continued until delivery. Children born at term to mothers recruited in Southampton were invited to participate in the childhood follow-up at ages 4 and 6–7 years.

The children underwent dual-energy X-ray absorptiometry (DXA, Hologic Discovery) scans of the whole body excluding the head (WBLH) and lumbar spine. Measurements assessed bone area, bone mineral content (BMC), bone mineral density (BMD), and bone mineral apparent density (BMAD). Linear regression analysis was applied to compare the two groups while adjusting for potential confounding factors such as age, sex, height, weight, duration of breastfeeding, and vitamin D use at ages 6–7 years.

The analysis uncovered the following findings:

  • A total of 454 children were followed up at ages 6–7 years, with 447 having a usable DXA scan.
  • Gestational cholecalciferol supplementation was associated with higher whole-body less head bone mineral content (WBLH BMC), bone mineral density (BMD), bone mineral apparent density (BMAD), and lean mass compared to the placebo group.
  • Specifically, WBLH BMC was 0.15 SD higher, BMD was 0.18 SD higher, and BMAD was 0.18 SD higher. Additionally, lean mass was 0.09 SD higher in the cholecalciferol group.
  • The effects of gestational cholecalciferol supplementation on bone outcomes were consistent at ages 4 and 6–7.

“We showed that pregnant women who took 1000 IU/day of cholecalciferol during pregnancy showed higher offspring bone mineral density (BMD) and lean mass in mid-childhood compared to those who received a placebo, according to an exploratory post-hoc analysis,” the researchers wrote.

“These findings highlight that vitamin D supplementation during pregnancy could serve as a key public health strategy to enhance bone health in children,” they concluded.

Reference:

Moon RJ, D’ Angelo S, Curtis EM, Ward KA, Crozier SR, Schoenmakers I, Javaid MK, Bishop NJ, Godfrey KM, Cooper C, Harvey NC; MAVIDOS Trial Group. Pregnancy vitamin D supplementation and offspring bone mineral density in childhood follow-up of a randomized controlled trial. Am J Clin Nutr. 2024 Nov;120(5):1134-1142. doi: 10.1016/j.ajcnut.2024.09.014. Epub 2024 Sep 19. PMID: 39306330; PMCID: PMC11600048.

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