MBBS seat scam busted! Man pretends to be a priest, dupes parents of crores promising admissions in Vellore’s Medical College

Thrissur: Police have arrested a 67-year-old man for duping parents of aspirants of crores of rupees by promising MBBS seats in a reputed Tamil Nadu medical college. The man reportedly pretended to be a priest to cheat people. He has now been arrested for allegedly running a scam by falsely promising MBBS seats under the staff quota at Vellore Medical College. The apprehended, Jacob Thomas of Koodal in Pathanamthitta, was arrested at the Chennai International Airport while attempting to flee to Malaysia.

Onmanorama Reports that Thomas introduced himself as a gospel worker and convinced families from Kerala and other states that he had close connections with Christian Medical College (CMC), Vellore, and an Anglican bishop.

Speaking to PTI, a police official informed, “A Pathanamthitta resident accused of duping parents of crores of rupees by promising MBBS seats in a reputed Tamil Nadu medical college has been arrested, the police said on Sunday. Jacob Thomas (67), taken into custody by the Thrissur West police, allegedly collected large sums of money from parents of MBBS aspirants in Kerala and other states last year, claiming he could secure seats under the staff quota at the medical college.”

According to a recent report by Kerala Kaumudi, Jacob Thomas swindled money from people from Kerala and outside the state by introducing himself as a priest.

Also Read:MBBS Seat Fraud: Maharashtra Businessman Swindled of Rs 51 Lakh

He was apprehended while attempting to flee to Malaysia via Chennai International Airport, the police officials added. Thomas, over these years, was reportedly implicated in multiple cases registered at police stations in Thrissur West, Angamaly, Koratty, Pala, Pandalam, and Adoor. Previously, four individuals were arrested in connection with the same case, police said.

Jacob Thomas duped parents of crores of rupees by promising them an MBBS seat in Tamil Nadu’s Vellore under staff quota, reports Kerala Kaumudi.

Thomas lived in seven states, including Bihar, Haryana, and Tamil Nadu, to evade arrest. During his stay in Thakkalai, Kanyakumari, he allegedly defrauded several people in Kerala. Victims have reported losing amounts ranging from Rs 60 lakh to Rs 80 lakh, adds Onmanorama

Also Read:Noida MBBS Admission Racket: 3 people arrested for duping over 50 MBBS aspirants

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Sidhu claims Diet Changes Cured His Wife’s Cancer, doctors warn against unscientific remedies

Amritsar: Controversy erupted after more than 260 oncologists criticized Navjot Kaur Sidhu for endorsing an Ayurvedic diet and simple lifestyle, which he credited for his wife’s cancer-free recovery. The doctors have dismissed these claims as unscientific and potentially harmful.

During a press conference
outside their Amritsar residence on Thursday, Navjot Singh Sidhu shared the
happy news that his wife, Navjot Kaur Sidhu, has been declared cancer-free. His
wife is a rare instance of someone beating metastatic, stage 4 cancer. His
remarks to the press covered her time spent in public hospitals, her adherence
to an ayurvedic diet, and the power of changes in lifestyle in combating
cancer.

A group of 262 oncologists, both current and former members of Tata Memorial Hospital, collectively issued a statement denouncing these measures as false. The statement serves as a public warning against relying on unproven remedies.

Dr CS Pramesh, the hospital’s director, described Sidhu’s claims as “unscientific and baseless.” Sharing the statement on social media, Dr Pramesh wrote, “These recommendations have no high-quality evidence to support them. She became cancer-free due to evidence-based treatments like surgery and chemotherapy, not turmeric or neem”, reports the Economic Times

Sidhu stated, “Doctors said there is less than 5% chance of survival for my wife, even an oncologist also said that there is no chance of survival. I
conducted research and started a special diet. She came back from the verge of
death within 40 days. People say fighting cancer is costly but Neem leaves do
not cost any money as such. Cancer cells start to die if one follows a proper diet. Cancer can be defeated with lifestyle changes.”

He kept on explaining the diets but forgot to mention that she had undergone her third Chemotherapy and surgery
facilitated by Dr Rupinder Batra (Former Tata Memorial Oncologist) at Waryam
Singh Hospital, Yamunanagar.

Dr Tushar Mehra
expressed dissatisfaction with Sidhu’s recent press release. He stated, “Pahji,
you came to a TV show & spoke about madam’s cancer journey and now this tweet
which mentions all about diet & ayurveda, etc. Not even once you mentioned
Dr Batra from Yamunanagar in the show who helped your whole family. I
am not against any ayurveda or diet plan that you said has worked for your wife
but I am appalled at your indifference to the real hero. At least do mention
the chemo and the magical role that it played in saving Madam Sidhu.”

Another doctor pointed
out, “Mentioned each and everything but forgot to mention the part about
surgery and chemo. Wow.” Another medical professional, Dr. Akash Mathur also
addressed Former Asst. Professor, Gastroenterology, Sanjay Gandhi Postgraduate
Institute of Medical Sciences stated, “Diet and nutrition play a crucial role
in fighting diseases, but let’s not forget that proper medical treatment is
essential. Celebrity statements often misguide—always consult a doctor for
accurate advice. Defeating cancer is possible but only with proper care.”

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NMC further Extends Deadline for medical colleges to Submit MBBS Admission Details

New Delhi: The National Medical Commission (NMC) has extended the deadline for submitting details of students admitted to the MBBS course for the academic year 2024-2025 to December 10th.

Earlier, an extension for the deadline was granted by the Commission after observing that many medical colleges/institutes have not filled or partially filled the required information till 23.11.2024 using the online portal of NMC.

It is mandatory for the medical colleges to provide NMC with the required information regarding admission to medical courses. Medical Dialogues had earlier reported that through a notice, the UG Board of NMC had asked all the medical colleges/institutes to submit their students’ admission details.

The NMC referred to the earlier notifitcaion in this regard and issued a notice recently informing all the Principal and Dean of the Medical Colleges and  Institutions of India regarding the extension of the Deadline for Online Filing of Admission Information for 1st Year MBBS Students (AY 2024-25)

The Undergraduate Medical Education Board (UGMEB) has extended the deadline for online submission of admission details for 1st-year MBBS students for the academic year 2024-25. Originally set for 23rd November 2024, the new deadline is 10th December 2024 (midnight). All stakeholders are requested to take note of this change and ensure compliance within the revised timeline.

“Reference is cited to letter no. U-16011/Circular/2024-25/UGMEB/M.Cell dated 20-11-2024 issued by the Under Graduate Medical Education Board (UGMEB) on the subject mentioned above enclosed herewith. wherein the last date to fill up the online details of Ist year MBBS Course admitted students for the academic year 2024-25 has now been extended from 23rd November, 2024 to 10thDecember, 2024 (midnight),All concerned stakeholders are requested to kindly take note of the same. “, stated the notice.

To view the official Notice, Click here : https://medicaldialogues.in/pdf_upload/document-105-1-261860.pdf

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64th NAMS Convocation at AIIMS Jodhpur held, ‘Healthy society a need to make Viksit Bharat!’ says Vice President Dhankhar

Jodhpur: The 64th convocation of National Academy of Medical Sciences (NAMS) was recently held at AIIMS Jodhpur,.

Highlighting the direct relation between health of an individual, productivity of the individual and the overall health of the society, Vice-President Shri Jagdeep Dhankhar said that, “Health is paramount and priority concern as good health is not only necessary for individual, not for our pursuits, but for the good health of the society. That broadly is also your theme. Friends, having good health is directly related to your productivity, as I said. If you are not healthy, your productivity will not be optimal. Rather than helping others, you might be seeking other’s help.”

Addressing the 64th convocation of National Academy of Medical Sciences (NAMS) at AIIMS Jodhpur, Shri Dhankhar expressed concern over the commercialization and ethical dilution in the medical profession. “Medical professionals serve as guardians and the role is all the more significant in Bharat that is home to one sixth of humanity. Your concern must be beyond clinical care. You have to be, and you have to engage in advocacy of good health. You have to become educators and public health advocates. But the challenges are there now in healthcare. The challenges are commercialization and ethical dilution is required to be addressed. Healthcare is a divine contribution. Healthcare is service. Healthcare has to be far distant from commerce, and health care is antithetical to exploitation”, he added.

Also Read:Vice President Jagdeep Dhankhar addresses 18th Foundation Day of ICMR, National Institute of Traditional Medicine

Underscoring the need of a healthy society to make ‘Viksit Bharat at 2047’, the Vice-President stressed, “ We are having exponential economic upsurge and phenomenal infrastructure growth. In the last few years, this has made Bharat, which once was part of fragile five economies, as big five global economies, on the way to becoming the third largest global economy.

Jagdeep Dhankhar

Vice-President Jagdeep Dhankhar Presides Over 64th NAMS Convocation at AIIMS Jodhpur

Jagdeep Dhankhar

Vice-President Jagdeep Dhankhar Presides Over 64th NAMS Convocation at AIIMS Jodhpur

Jagdeep Dhankhar

Vice-President Jagdeep Dhankhar Presides Over 64th NAMS Convocation at AIIMS Jodhpur

But friends, this aspirational object, very ambitious, requires an 8 fold increase in our per capita income, and this takes me to something which is of your interest. This is attainable only with our population being healthy and fit. One may be committed, sincere, earnest, gifted, devoted, but if that person is not physically healthy, rather than helping the society at large with his dedication and expertise, he will be seeking help. And therefore it is essential that everyone in the country remains healthy”.

Urging the industry leaders to support manufacturing of medical equipment in India, Shri Dhankhar said, “ We must engage and strongly champion locally manufactured medical equipment. Let us demolish the myth – imported items are superior; not any longer. Through this platform I will urge Indian industry, business, trade and commerce to engage into activities of making medical equipment in the country for the nation, also for the world.”

Advocating for a preventive wellness education and cautioning against the risks of digital lifestyle Shri Dhankhar stated, “ I strongly advocate and plead with health care experts, please champion preventive wellness education with a special focus on combating, and this is something new, this is rampant and this is digital lifestyle. This digital lifestyle is coming with risks.

That may be existential. I would urge; it is your ordainment to educate families so that they take care of it right from the beginning. We are having youth engaging into drugs, getting into depression, having mental stress and mental stress in a country which according to the IMF is a favourite global destination of investment and opportunity. Therefore they require massive hand-holding to get them away from their attraction with screen dominated world.”

Underlining the focus on good health in our ancient text and scriptures, Shri Dhankhar said that, “ हमारे ऋषि मुनि कह गए और बहुत सही बात कह गए, पहला सुख निरोगी काया ! They put health as a priority, in precedence to everything else. Health, for being, is fundamental and quintessential to one’s making contribution to society. Health, friends, is not just absence of illness, but a state of holistic well-being. Our Vedas, our Puranas, our Upanishads are gold mine of wisdom and knowledge. We need to bestow attention on them. It emanates from them. I quote, “प्रसन्न इन्द्रिय, मन, आत्मन:” The harmony between mind, body and spirit. That is essential for a person to perform and be a complete human being.”

Emphasising on the importance of moderation in life Shri Dhankhar invited attention to ‘Bhagvad Gita’ and stated, “ I would particularly seek to invite attention to a verse in Bhagavad Gita. You would recall the eighteen chapters, if you go through them, they contain ultimate sublimity of wisdom. I am referring to verse sixteen in chapter six.

नात्यश्नतस्तु योगोऽस्ति न चैकान्तमनश्नत:

न चाति स्वप्नशीलस्य जाग्रतो नैव चार्जुन

Now mark what it says, moderation in diet, moderation in thinking, recreation and action are key to healthy living. Lord Krishna indicates, eating too much food or starving, the two extremes, and sleeping too much or remaining awake all the time is not health-friendly.”

Dr. Shiv Sarin, President, NAMS, Dr. Punya Salila Srivastava, IAS, Secretary Health & Family Welfare, Government of India, Dr. Rajesh Sudhir Gokhale, Secretary, Department of Biotechnology, Government of India, Dr. G. D. Puri, Director, AIIMS Jodhpur and other dignitaries were also present on the occasion.

Also Read:’Doctors should keep growing their knowledge’, says President Droupadi Murmu at 2nd Convocation Of AIIMS Raipur

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MPDME begins NEET 2024 Special Stray Vacancy Round Counselling, see Schedule

Madhya Pradesh- Office of Commissioner Medical Education Bhopal, Madhya Pradesh has begun the MP State Combined National Eligibility and Entrance Tet-Undergraduate (NEET UG) Special Stray Vacancy Round Counselling for the academic year 2024. On this, the Director of Medical Education (DME) MP has released the complete schedule for the candidates of the said counselling on its official website.

As per the schedule, the NEET UG Special Stray Vacancy Round Counselling 2024 process will begin on November 25, 2024, and end on December 05, 2024. On 25th November the remaining vacancies and list of eligible candidates will be published, from 26th November to 01st December online application process by the eligible candidate on the portal against vacancies will start. Following this, from 3rd December reporting at the college will begin and from 5th December the admission process will begin.

Below is the detailed schedule-

SCHEDULE

S.NO

EVENTS

DURATION

NO. OF DAYS

1

Publication of Remaining Vacancies and list of eligible candidates.

25 November 2024

1 Day

2

Invitation of online application (choice-filling) by the eligible candidate on the portal against vacancies. Real-time College wise merit list of applicants 10 times the number of college vacancies on the portal.

26 November 2024 to 01 December 2024 (till 11:59 PM Midnight)

6 Days

3

Reporting at college for Online Attendance.

03 to 04 December 2024 (10:00 AM to 05:00 PM)

2 Days

4

Admission (selected candidate as per attendance merit)

05 December 2024 (12:00 Noon to 05:00 PM)

1 Day

NEET UG 2024 Special Stray Vacancy Round Counselling 2024 is being conducted to fill the remaining vacant seats. Directorate of Medical Education (DME) is a department of Madhya Pradesh Medical University (MPMSU) that provides counselling for courses and departments related to medical education. MPDME provides undergraduate counselling, postgraduate counselling, nursing counselling, MPMC, FMG counselling, and clinical clerkship/internship. 

To view the schedule, click the link below

https://medicaldialogues.in/pdf_upload/schedule-261986.pdf

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GLP1 Receptor Agonists reduce VTE risk in Type 2 Diabetes, claims research

A recent groundbreaking study
found that Glucagon-like peptide 1 receptor agonists (GLP1-RA) are effective in
reducing venous thromboembolism (VTE) in type 2 diabetics regardless of their
obesity status. The study results were presented at the Annual Meeting &
Exposition of the American Society of Hematology.

Glucagon-like peptide 1 receptor
agonists (GLP1-RA) are antihyperglycemic agents used for the treatment of type
2 diabetes mellitus (T2DM) which is a global pandemic. They are also prescribed
for weight loss in obese patients. Research shows a consistent cardiovascular
benefit with the use of GLP1-RA in T2DM. Previous studies have shown that
GLP1-RA may reduce the thromboxane-induced platelet activation. As obesity is one
of the risk factors for venous thromboembolism (VTE) researchers hypothesized
that GLP1-RA use may reduce the risk of VTE.

A retrospective, propensity
score-matched multicenter database analysis was carried out using the TriNetX
Analytics Network. Individuals with T2DM were taken for the study as diabetics
use GLP1-RA. Individuals using oral anticoagulation, prior VTE, or a history of
atrial fibrillation were excluded from the study.

Comparisons were done between patients
who received GLP1-RA with those who received Dipeptidyl Peptidase-4 (DPP-4)
inhibitors for achieving glycemic control. A subgroup analysis was also
performed stratified by the presence of obesity. An individual was considered
obese if they have a body mass index (BMI) 30 kg/m2. The primary
outcome was incidence rate per 1000-patient years of all VTE at 1-year after
the index date of first initiation of GLP1-RA or DPP-4 inhibitors. pulmonary
embolism (PE) and deep venous thrombosis (DVT) measured individually were the
secondary outcomes.

propensity-matching was done to
patients (1:1) taking GLP1-RA with those on DPP-4 inhibitors based on
predetermined clinical variables, including age, sex, race, BMI, hemoglobin
A1c, use of other anti-diabetic agents including metformin and insulin, and
underlying comorbidities. Charleston Comorbidity index was used for the
propensity matching. a subgroup analysis was carried out as a secondary
analysis stratified by the presence of obesity.

Findings:

  • About 6,56,588 eligible patients who had T2DM were
    identified of whom 366,369 received GLP1-RA and 290,219 received DPP-4
    inhibitors, respectively.
  • Among patients with known BMI data, 62% of the
    patients were classified as obese with a BMI of 30kg/m2.
  • Two cohorts ach having 168,428 patients were included
    in the final analysis who received GLP1-RA and DPP-4 inhibitors after
    propensity-score matching.
  • Both cohorts were well balanced for
    demographics, hemoglobin A1c, BMI, other anti-diabetic drugs, and preexisting
    comorbidities.
  • The mean HbA1c were 8.3 ± 2.0 and 8.3 ± 2.0,
    and the mean BMI was 33.3 ± 7.4 and 32.4 ± 7.1 for patients on GLP1-RA and
    DPP-4 inhibitors, respectively.
  • The incidence of VTE was 11.0 events per 1000
    patient-years in the GLP1-RA cohort vs. 12.9 in the DPP-4 inhibitor cohort indicating
    that GLP1-RA decreased the VTE.
  • Patients who received GLP1-RA had an 18% lower
    risk of VTE than those who received DPP-4 inhibitors.
  • Similarly, patients who received GLP1-RA had a
    lower risk of PE and DVT than those on DPP-4 inhibitors.
  • In the subgroup analysis, similar differences in
    VTE rates were observed in patients with obesity and without obesity.

Thus, the study concluded that
GLP1-RA reduces the risk of VTE and has a potential beyond glycemic control in
individuals with obesity and type 2 diabetes.

Further reading:

Glucagon-like Peptide 1
Receptor Agonists Reduce the Risk of Venous Thromboembolism in Patients with
Diabetes Irrespective of Obesity: A Propensity Score-Matched Multicenter
Database Analysis. Oral and Poster Abstracts. Poster No.701.

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Apollo Institute of Medical Sciences and Research hosts White Coat Ceremony for 2024 MBBS batch

Hyderabad: Recently, the Apollo Institute of Medical Sciences & Research (AIMSR) Hyderabad; hosted the White Coat Ceremony, for the MBBS Class of 2024 students, at the RNR Auditorium, Jubilee Hills.

White Coat Ceremony is a memorable experience for students taking their initial steps into the noble profession of Medicine, by joining the medical school. One hundred and fifty students of the 2024 batch of the Apollo Institute of Medical Sciences & Research, were welcomed into the medical fraternity by the faculty and were ceremonially “cloaked” with their white aprons. The students dressed elegantly in white, later took the Hippocrates oath, traditionally sworn at graduation.

Chief Guest Dr. Rooma Sinha, Honorary Professor, Gynecology, Apollo Hospitals; presented the White Coats to students on the occasion. Ms. Aparna Reddy, COO, AIMSR; Dr. K. Manohar, Dean, Apollo Institute of Medical Sciences & Research; along with the faculty from the Institute and parents of students, were present to catch a glimpse of the momentous occasion.

Speaking on the occasion Dr. Rooma Sinha said, “Being a medical student is a life changing event, the two most important attributes to be a doctor are intelligence and hard work, and you have both, because of which you are here. One thing I believe very much, and you must inculcate from today that you are the best advocate for your patient, you need to live up to the trust your patient comes to you with.”

“You need to give him the best advice that you can, if you can’t collaborate with someone and give the best advice, which leaves an impression that you are their best advocate. When you converse with the patient be calm and confident for the patient to trust in what you are doing. Patients don’t need sympathy, they want someone who empathizes with their problem and tries to find a solution for it, therefore empathy with the patient is critical.” she added.

Also Read:White Coat Ceremony held at at Virudhunagar government medical college

“Honesty is an attribute we need to imbibe, if you don’t know what the patient is suffering from, don’t do what you know, make sure the patient gets the right treatment, the right advice, your honesty will come back to you, if the patient gets better with your advice, they will remember you for life time, that’s the respect a doctor earns in his life, no other profession has that privilege. Be passionate about what you are doing, medicine won’t work without passion.”

Apollo Institute of Medical Sciences & Research

Apollo Institute of Medical Sciences & Research hosts ‘White Coat Ceremony’ to welcome the Class of 2024 students!

Apollo Institute of Medical Sciences & Research

Apollo Institute of Medical Sciences & Research hosts ‘White Coat Ceremony’ to welcome the Class of 2024 students!

Dr. K. Manohar said, “The white coat ceremony marks the beginning of a student’s medical career. This phase needs the utmost attention from each student to lay a strong foundation for the medical career ahead.What we are doing at Apollo is different from any other college in the state. We are the first and the only institute to comply with the CBME curriculum in India and we introduced last year the taking up of proposal of research by the students in the first year itself, they go for data collection with the help of the mentor in the second phase and write the paper in the third year, so that you have good experience of doing some original research work in the field, this will be helpful in the wonderful program designed by NMC called family adoption program.”

Right from the first phase you are exposed to the society and people and develop a rich experience of communicating and understanding the disease profile in the society, which helps to formulate the problems the society is facing. These experiences will pave the way for brighter future for the students. Medicine is not like other streams, the day when you cease to read, your practice may come to an end, studying is an ongoing process, learning doesn’t stop with fetching a degree, till we die we need to continue updating our knowledge, he added.

Ms. Aparna Reddy said, as you begin your medical journey I urge you to remember the oath you take today, remember the commitment you make to uphold the high standards of professionalism, to respect the autonomy and dignity of the patients and to provide compassionate and evidence based care.

Also Read:Apollo Institute of Medical Sciences and Research Holds 3rd graduation ceremony, 200 MBBS students receive Degree Certificates

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Elevated Remnant Cholesterol tied to increased ASCVD events in Individuals With Diabetes: Study

Elevated Remnant Cholesterol tied to increased ASCVD events in Individuals With Diabetes suggests a study published in the Diabetes/Metabolism Research and Reviews.

Elevated remnant cholesterol (= the cholesterol carried in triglyceride-rich lipoproteins) is a causal risk factor for atherosclerotic cardiovascular disease (ASCVD) and is common in individuals with diabetes. They tested the hypothesis that ASCVD in individuals with diabetes can be partly attributed to elevated remnant cholesterol.

They included 3806 individuals with diabetes identified among 107,243 individuals from the Copenhagen General Population Study and used multivariable adjusted Poisson regression to estimate the fraction of ASCVD attributable to elevated remnant cholesterol. Elevated remnant cholesterol was defined as levels higher than those observed in individuals with non-high-density lipoprotein (non-HDL) cholesterol < 2.6 mmol/L (100 mg/dL), the European guideline goal. Results were replicated in the UK Biobank. Results: During 15 years of follow-up, 498 patients were diagnosed with ASCVD, 172 with peripheral artery disease, 185 with myocardial infarction and 195 with ischaemic stroke. In individuals with non-HDL cholesterol < 2.6 mmol/L (100 mg/dL) and in all individuals with diabetes, median remnant cholesterol levels were 0.5 mmol/L (20 mg/dL) and 0.8 mmol/L (31 mg/dL).

The fraction of events attributable to elevated remnant cholesterol was 19% (95% confidence interval: 10%-28%) for ASCVD, 21% (5%-37%) for peripheral artery disease, 24% (10%-37%) for myocardial infarction and 17% (1%-31%) for ischaemic stroke; in the UK Biobank, corresponding values were 16% (9%-22%), 25% (12%-36%), 17% (8%-25%) and 7% (0%-19%), respectively. One in five ASCVD events in individuals with diabetes can be attributed to elevated remnant cholesterol. It remains to be determined in clinical trials if remnant cholesterol-lowering therapy may prevent ASCVD.

Reference:

Wadström BN, Pedersen KM, Wulff AB, Nordestgaard BG. One in Five Atherosclerotic Cardiovascular Disease Events in Individuals With Diabetes Attributed to Elevated Remnant Cholesterol. Diabetes Metab Res Rev. 2024 Nov;40(8):e70005. doi: 10.1002/dmrr.70005. PMID: 39550770.

 

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LDL-C and lipoprotein(a) levels independently and additively associated with ASCVD risk: Study

The results of a recent study that was published in the journal of Circulation, suggest that low-density lipoprotein cholesterol (LDL-C) and lipoprotein(a) (Lp[a]) levels are independent and additive for atherosclerotic cardiovascular disease (ASCVD) risk, and lowering LDL-C does not completely counteract Lp(a)-mediated risk.

Lp(a), which is mostly genetically driven, has been demonstrated to be an independent predictor of calcific aortic stenosis and ASCVD risk. Numerous genetic studies have demonstrated a link between elevated Lp(a) and cardiovascular disease, and several treatments are being developed to reduce and treat it. According to US standards, Lp(a) is regarded as a “risk enhancer,” a surrogate that can assist certain patients in making treatment decisions. Some guidelines, including those from the European Atherosclerosis Society and the National Lipid Association, suggest being more aggressive with LDL reduction to counter the risk associated with high Lp(a) in the absence of effective medications.

To evaluate the relationship between LDL-C and Lp(a) levels and the risk of stroke, coronary heart disease events, or any coronary or carotid revascularization, a participant-level meta-analysis of 27,658 patients included in six placebo-controlled statin trials was conducted. Generalized additive models were used to continuously model the multivariable-adjusted relationship between baseline Lp(a) level and ASCVD risk, and Cox proportional hazards models with random effects were used to model the relationship between baseline LDL-C level and ASCVD risk by baseline Lp(a) level. Cox proportional hazards models were used to assess the combined relationship between ASCVD risk and Lp(a) level and statin-achieved LDL-C level.

In patients receiving statins and placebos, rising Lp(a) levels were log-linearly linked to an increased risk of ASCVD when compared to a level of 5 mg/dL. All quartiles of the attained LDL-C level and the absolute change in LDL-C level were associated with increased risk among statin-treated people whose Lp(a) level was more than 50 mg/dL (≈125 nmol/L).

The risk of ASCVD was higher for the ones with Lp(a) levels >50 mg/dL than for the ones with Lp(a) levels ≤50 mg/dL, even among the individuals with the lowest quartile of attained LDL-C levels (3.1–77.0 mg/dL). LDL-C levels in the fourth quartile and Lp(a) levels greater than 50 mg/dL were associated with the highest risk. Overall, greater levels of lipoprotein (a) are linked to a greater risk of cardiovascular disease events in individuals with low LDL cholesterol, including the ones who have very significant absolute reductions with statin medication.

Source:

Bhatia, H. S., Wandel, S., Willeit, P., Lesogor, A., Bailey, K., Ridker, P. M., Nestel, P., Simes, J., Tonkin, A., Schwartz, G. G., Colhoun, H., Wanner, C., & Tsimikas, S. (2024). Independence of Lipoprotein(a) and Low-Density Lipoprotein Cholesterol–Mediated Cardiovascular Risk: A Participant-Level Meta-Analysis. In Circulation. Ovid Technologies (Wolters Kluwer Health). https://doi.org/10.1161/circulationaha.124.069556

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Study Explores the Potential of Ciprofol Compared to Propofol for anesthesia induction in cardiac surgery

The increasing occurrence of heart diseases like coronary heart disease and heart valve disease is linked to demographic changes and an aging populace. Patients who do not respond well to medical interventions may require cardiac surgery, posing challenges due to substantial hemodynamic variations during anesthesia induction and a higher risk of adverse events. Propofol is frequently used for anesthesia induction in different surgeries, including cardiac procedures, despite its notable impact on cardiovascular and respiratory functions and the rare but serious propofol infusion syndrome.Recent study examines the safety and hemodynamic effects of the novel intravenous general anesthetic Ciprofol compared to Propofol for anesthesia induction in cardiac surgery patients. Ciprofol is a recently developed sedative with greater potency than Propofol and a chiral structure that enhances its affinity for GABAA receptors.

The study enrolled 78 patients undergoing coronary artery bypass grafting or heart valve replacement surgery, who were randomly assigned to receive either Ciprofol or Propofol for anesthesia induction. The primary outcome was to evaluate hemodynamic fluctuations, specifically changes in mean arterial pressure (MAP) and heart rate (HR) during anesthesia induction. Secondary outcomes included the incidence of injection pain, latency to loss of corneal reflex, oxygen saturation, and oxygenation index.

Comparison of Groups

The results showed no significant differences in MAP and HR changes between the Ciprofol and Propofol groups during anesthesia induction. The incidence of anesthesia-induced injection pain was significantly lower in the Ciprofol group compared to the Propofol group (3% vs. 18%, p<0.05). However, there were no significant differences in the incidence of adverse events such as hypotension, bradycardia, and the use of vasopressors and anticholinergics between the two groups.

Oxygenation and Metabolic Effects

Oxygenation parameters and lactate concentration were also comparable between the groups, indicating similar respiratory and metabolic effects of Ciprofol and Propofol. These findings suggest that Ciprofol provides similar hemodynamic stability to Propofol during anesthesia induction in cardiac surgery, while offering the advantage of reduced injection pain. The study is limited by its small sample size, which may have been underpowered to fully capture differences in adverse events. Additionally, the study only included patients with moderate cardiac dysfunction, and the long-term outcomes were not assessed. Further research is needed to evaluate the broader clinical implications and potential advantages of Ciprofol in various cardiac surgery patient populations.

Key Points

1. The study examined the safety and hemodynamic effects of the novel intravenous general anesthetic Ciprofol compared to Propofol for anesthesia induction in cardiac surgery patients.

2. The study enrolled 78 patients undergoing coronary artery bypass grafting or heart valve replacement surgery, who were randomly assigned to receive either Ciprofol or Propofol for anesthesia induction.

3. The primary outcome was to evaluate hemodynamic fluctuations, specifically changes in mean arterial pressure (MAP) and heart rate (HR) during anesthesia induction. Secondary outcomes included the incidence of injection pain, latency to loss of corneal reflex, oxygen saturation, and oxygenation index.

4. The results showed no significant differences in MAP and HR changes between the Ciprofol and Propofol groups during anesthesia induction. The incidence of anesthesia-induced injection pain was significantly lower in the Ciprofol group compared to the Propofol group.

5. Oxygenation parameters and lactate concentration were also comparable between the groups, indicating similar respiratory and metabolic effects of Ciprofol and Propofol.

6. The study is limited by its small sample size and only included patients with moderate cardiac dysfunction, and the long-term outcomes were not assessed. Further research is needed to evaluate the broader clinical implications and potential advantages of Ciprofol in various cardiac surgery patient populations.

Reference –

Yu, L., Liu, X., Zhao, X. et al. Ciprofol versus propofol for anesthesia induction in cardiac surgery: a randomized double-blind controlled clinical trial. BMC Anesthesiol 24, 412 (2024). https://doi.org/10.1186/s12871-024-02795-0

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