Archive for month: October, 2024

New Delhi: The drug major Pfizer has got approval from the Subject Expert Committee (SEC) functional under the Central Drug Standard Control Organisation (CDSCO) to conduct the phase 2A clinical study of the antimicrobial drug combination Avibactam 0.5 g plus Aztreonam 1.5 g Powder for Concentrate for Solution for Infusion.

This came after the firm presented phase 2A clinical study protocol no. C3601010 dated 27 September 2023.

Avibactam is a non-β-lactam β-lactamase inhibitor used in combination with ceftazidime for the treatment of complicated intra-abdominal infections, complicated urinary tract infections, and hospital or ventilator-acquired pneumonia.

Avibactam is a non-β lactam β-lactamase inhibitor that inactivates some β-lactamases (Ambler class A β-lactamases, including Klebsiella pneumoniae carbapenemases, Ambler class C and some Ambler class D β-lactamases) by a unique covalent and reversible mechanism, and protects ceftazidime from degradation by certain β-lactamases. Avibactam rapidly reaches the periplasm of bacteria at high enough concentrations to restore activity of ceftazidime against ceftazidime-resistant, β-lactamase-producing strains. Avibactam does not decrease the activity of ceftazidime against ceftazidime­ susceptible organisms.

Aztreonam is a beta-lactam antibiotic used to treat select aztreonam-sensitive gram-negative bacteria.

The bactericidal action of aztreonam results from the inhibition of bacterial cell wall synthesis due to a high affinity of aztreonam for penicillin binding protein 3 (PBP3). By binding to PBP3, aztreonam inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins. It is possible that aztreonam interferes with an autolysin inhibitor.

At the recent SEC meeting for Antimicrobial and Antiviral held on September 19, 2024, the expert panel reviewed the phase 2A clinical study protocol no. C3601010 dated 27 September 2023 presented by the drug major Pfizer.

After detailed deliberation, the committee recommended the grant of permission to conduct the trial as presented by the firm.

Also Read:Torsemide, Dapagliflozin FDC not rational: CDSCO Panel Rejects Syngene’s Proposal for BA/BE study

Eye hospital, Ophthalmologists slapped Rs 15 Lakh compensation for vision loss due to Surgical Negligence

Holding a private eye institute, its director and two ophthalmologists guilty of medical negligence, the District Consumer Disputes Redressal Commission-II, Visakhapatnam directed them to pay Rs 15 lakh to the patient who lost vision in one eye.

The history of the case goes back to February 2019 when the patient was chatting with his friend while another friend was playing with an air rifle. One of the pellets from the air rifle touched the complainant’s left eye and due to this, he sustained bleeding injury.

For more details, click the link below

Vision loss due to negligence in surgery: Eye Hospital, ophthalmologists slapped Rs 15 lakh Compensation

HC attaches salary of State Health Secretary as hospitals unpaid despite Ayushman Bharat funds release

While considering the pleas filed by several hospitals in Punjab seeking the release of pending dues from the State Government under the Ayushman Bharat Scheme, the Punjab and Haryana High Court till October 16, attached the salaries of senior officials, including the Principal Secretary of the Health Department of the State, for failing to release the pending dues.

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Hospitals Not Paid Despite Release of Funds Under Ayushman Bharat: HC Attaches Salary of State Health Secretary among Others

Andhra announces NEET PG bond policy: 10 Years service, Rs 50 lakh penalty for in-service candidates

Doctors getting admitted to PG medical courses (degree and diploma) in the Competent Authority Quota seats at Andhra Pradesh-based Dr. NTR University of Health Sciences will have to compulsorily serve the State Government or pay a penalty of Rs 40 lakh and Rs 50 lakh

In the case of service candidates, they will have to serve the State Government for a minimum period of 10 years after completion of in-service PG Degree/Super Specialty course in any Government institution/health facility of the State. For them, the amount of bond penalty is Rs 50 lakh, in addition to the pay and allowances received during the years of study.

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10 years of service, Rs 50 lakh penalty for Inservice candidates: Andhra notifies bond policy for NEET PG admissions this year

Homoeopathic doctor and 5 others arrested for running drug racket,
Rs 4.2 crore worth anxiety drug seized

Busting an illegal supply of drugs racket in the capital, the Delhi police recently arrested a homoeopathic doctor previously honoured with the prestigious Indian Achiever’s Award along with five others for illegally manufacturing Alprazolam, a psychotropic drug used to treat anxiety disorders.

According to the police, around 18 kg of Alprazolam powder was recovered in the possession of one of the accused Rajender Prasad Mishra who worked as a carrier in a drug cartel involved in the racket. Additionally, the police recovered the drugs worth Rs 4.20 crore from the accused.

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Homoeopathic doctor, 5 others arrested for running psychotropic drug manufacturing racket, 4.2 crore drug seized

UP medical student allegedly dies by suicide in Car

A 28-year-old Master of Surgery
student from Moti Lal Nehru Medical College has reportedly died by suicide in
his car at a hospital affiliated with the college, according to police reports
on Sunday.

According to DCP (City) Abhishek
Bharti, doctors at SRN Hospital reported on Saturday night that a medical
professional working at the hospital had committed suicide.

The individual, a resident of Kotdwar
in Uttarakhand, is believed to have injected himself with a poisonous
substance. ACP Kotwali Manoj Kumar Singh stated that a field unit, dog squad,
and surveillance team have been dispatched to the scene, and evidence is
currently being collected.