RG Kar Case: Doctors, PG Residents File Intervention pleas Before Supreme Court

New Delhi: The Supreme Court bench comprising the Chief Justice of India DY Chandrachud has listed the RG Kar case for further hearing today i.e. August 22, 2024.

Meanwhile, associations of doctors and resident doctors have filed interventions in the matter. Approaching the Apex Court bench, the Delhi Medical Association (DMA) has prayed for directions to the National Medical Commission (NMC) and the State Health authorities to make safety at workplace & basic amenities, as mentioned in the Supreme Court order, a mandatory criteria for recognition of medical colleges and hospitals.

An intervention has also been filed by the National Federation of Resident Doctors of the All India Institute of Medical Association (AIIMS), which highlighted the concerns of various resident doctors in all AIIMS across the country.

The United Doctors Front Association (UDFA) has also approached the Apex Court with various prayers to effectively deal with the issue at hand and other connected matters that directly impact the welfare of the healthcare service personnel and the functioning of healthcare institutions across the country. Among them are formation of the Central Protection Act (CPA) Committee to address the critical concerns of healthcare professionals, ANI has reported.

Doctors and resident doctors filed these intervention applications in the case concerning the brutal rape and murder of a PG medical student at Kolkata-based RG Kar Medical College and Hospital. Recently, the Apex Court bench took suo motu cognizance of the matter and during the hearing of the case on Tuesday, the top court constituted a National Task Force comprising of nine doctors and five ex-officio members to draft an action plan to ensure the safety of the doctors, residents, interns, nurses and other healthcare professionals across the country.

This Task Force has been directed to submit its interim report within 3 weeks and the final report within 2 months before the Supreme Court bench. Listing the matter for further hearing on Thursday, the Supreme Court bench had asked the Central Bureau of Investigation (CBI) to file a status report into the RG Kar incident.

Intervention by DMA: 

After filing an intervention into the matter, DMA yesterday made an submission before the Apex Court and demanded the following:

1) Directions to NMC & State Health Authorities to make Safety at Workplace & basic amenities as mentioned in Court Order a Mandatory Criteria for recognition of Medical Colleges and Hospitals.

2) Mandatory Filing of Institutional FIR within 2 Hours

3)Creation of Compensation Distress Fund for victim & family.

4) Inclusion of DMA Representative on the Task Force.

Intervention by National Federation of Resident Doctors: 

ANI has reported that the National Federation of Resident Doctors of AIIMS has moved an intervention application in the Supreme Court, highlighting the concerns of various resident doctors in all AIIMS across the country.

Advocate Tanvi Dubey is representing the National Federation of Resident Doctors of AIIMS. The federation highlighted the concerns of various resident doctors in all AIIMS across the country and urged the top court for interim measures for the doctors till the recommendations made by the NTF are implemented.

The organisation has also mentioned that, by the very nature of their profession, healthcare workers are entitled to a certain degree of protection and safety mechanisms at the workplace.

Intervention by United Doctors Front Association (UDFA): 

UDFA, which is a collective organization representing doctors and healthcare professionals across India and committed to advocating for the rights, welfare, and professional interests of medical practitioners, said, “In light of the increasing instances of violence against healthcare professionals, there is an urgent need to revisit and enhance the existing legal framework to ensure their safety and security.”

The association urged the top court to recognize the significance of this legislative proposal and support its swift enactment. “Such legal protection is vital for maintaining the integrity of the healthcare system, safeguarding the rights of those who serve in it, and ensuring that the public continues to receive uninterrupted and quality healthcare services,” the application said.

UDFA has made various prayers to the top court to effectively deal with the issue at hand and other connected matters that directly impact the welfare of healthcare service personnel and the functioning of healthcare institutions across the country. Among them are the formation of the Central Protection Act (CPA) Committee to address the critical concerns of healthcare professionals.

Among others are request for ordinance, representation of youth in National Task Force, immediate Implementation of the NDMC Health Professional Violence Act as an interim measure until the CPA is enacted, issuance of directions to the Central Government to urgently formulate and implement uniform safety protocols across all healthcare institutions and deployment of a trained and designated security force at sensitive hospitals and medical institutions.

Also Read: Breaking News on RG Kar Case: Supreme Court Constitutes National Task Force to draft Action plan for Safety of Doctors

Powered by WPeMatico

Teenage Egg Donor Death Case: Bombay HC exonerates 3 IVF Clinic doctors from negligence charges

Mumbai: Noting that there was no sufficient ground for holding them negligent, the Bombay High Court has recently cleared three doctors associated with an IVF clinic located in Bandra West of any wrongdoing, following allegations of negligence that led to the death of a minor girl in an egg donor back in 2010. 

The doctors in this case were previously booked by the police for performing the procedures in their clinic and were held accountable for the death of the girl. However, the court disposed of the charges against them on August 9 and discharged them on August 16. 

During the court session, a single-judge bench of Justice RM Joshi said, “They cannot be held responsible for negligence, as they were not involved in the last egg removal which was perceived to be the cause of death of the girl. After the girl’s death, a medical opinion was sought about the cause of her death and negligence, if any, and a committee of doctors from Grant Medical College opined that it was a case of medical negligence. The opinion clarified that there was no evidence of anaesthetic complications or trauma to internal organs, which could have caused death.

Also read- Bombay HC Quashes Rape Case Against Doctor, imposes Rs 5 lakh fine

“It is thus clear that insofar as present applicants are concerned, they cannot be held responsible for the admission of an underaged patient to the hospital for the performance of the procedure. It cannot be said there was any medical negligence on their part which has resulted in causing the unfortunate death of the deceased,” added the court. 

As per HT news report, the case traces back to August 7, 2010, when the teenage girl, who worked at a scrap godown, did not return home. Her mother, concerned about her absence, approached the girl’s employer, who reassured her that the girl would return safely. The following day, the girl returned home but was unable to explain her whereabouts, as she had reportedly been administered an unknown substance that rendered her unconscious.

Shortly after her return, the teenager began experiencing severe abdominal pain. She was initially treated by a local doctor, but as her condition worsened, she was taken to Rajawadi Hospital and later referred to a civic hospital. Unfortunately, the girl died en route to the hospital.

A postmortem examination revealed multiple injuries and injection marks on the girl’s body, leading the Sakinaka police to launch an investigation. The probe uncovered that the minor had been used as an egg donor at a fertility clinic, despite regulations prohibiting minors from donating eggs at that time. The girl had donated eggs on three occasions: October 22, 2009, February 15, 2010, and August 8, 2010—the day she had gone missing.

The doctors associated with the fertility clinic were subsequently charged with negligence in connection to the girl’s death. However, three of the accused doctors challenged the charges in the Bombay High Court, following a sessions court’s refusal to discharge them on May 25, 2023. 

Following this, the court found the doctors not guilty of the medical negligence charges and discharged them accordingly. 

Also read- Patient’s death case at GMCH Chandigarh: No medical negligence, says hospital panel

Powered by WPeMatico

Soup and Shake Diet Intervention Effective in Attaining Type 2 Diabetes Remission , claims Lancet study

A new study published in The Lancet Diabetes & Endocrinology journal suggests that through at-scale service delivery, type 2 diabetes can be remitted outside of research settings. Total diet replacement (TDR) has been found in randomized controlled studies to be effective in type 2 diabetes remission. The NHS Type 2 Diabetes Path to Remission (T2DR) program, a 12-month behavioral intervention to support weight loss that involves an initial 3-month period of TDR, was developed in response to the English National Health Service’s (NHS) 2019 commitment to establishing a TDR-based interventional program delivered at scale within real-world environments. Thus, this study by Jonathan Valabhji and colleagues evaluated program participants of type 2 diabetes remission.

As part of a nationwide prospective service assessment the people in England between the ages of 18 and 65 who had been diagnosed with type 2 diabetes within the previous 6 years. The National Diabetes Audit and program data were connected to determine HbA1c values and prescriptions for medications that decrease blood sugar. Remission of type 2 diabetes at 1 year was the main outcome, which was outlined as two HbA1c measurements of less than 48 mmol/mol reported at least 3 months apart and no prescription for glucose-lowering drugs starting 3 months prior to the first HbA1c measurement and the second HbA1c measurement recorded 11 to 15 months after the start of program.

A total of 7540 participants were referred to the program between September 1, 2020, and December 31, 2022. Of which, 1740 began TDR prior to January 2022, giving them a full year to complete the program by the time data extraction took place at the end of December 2022. 960 people (55%) of the participants who began TDR prior to January 2022, finished the program.

There was an average weight reduction of 8·3% or 9·4 kg for the 1710 individuals who began the program before January 2022 and had no missing data, and an average weight loss of 9·3% or 10·3 kg for the 945 participants who finished the program and had no missing data. In a subset of 710 (42%) of 1710 patients who began the treatment before January 2022 and had two HbA1c measures recorded, 190 (27%) experienced remission, with a mean weight reduction of 13·4% or 14·8 kg. Of the 945 patients who finished the program, 450 (48%) had two HbA1c values recorded. 145 (32%) experienced remission, with a mean weight reduction of 14·4% or 15·9 kg.

Source:

Valabhji, J., Gorton, T., Barron, E., Safazadeh, S., Earnshaw, F., Helm, C., Virr, M., Kernan, J., Crowe, S., Aveyard, P., Wilding, J., Willis, T., Ells, L., O’Neill, S., Robertson, E., Jebb, S., Taylor, R., & Bakhai, C. (2024). Early findings from the NHS Type 2 Diabetes Path to Remission Programme: a prospective evaluation of real-world implementation. In The Lancet Diabetes & Endocrinology. Elsevier BV. https://doi.org/10.1016/s2213-8587(24)00194-3

Powered by WPeMatico

KNRUHS Invites Applications For MDS Admissions 2024 under management quota, Registration deadline Ends Tomorrow

Telanagan- Kaloji Narayan Rao University of Health Sciences (KNRUHS) si going to close the application window for National Eligibility and Entrance Test-Master of Dental Surgery (NEET MDS) 2024 qualified candidates from Indian Nationals, OCI, PIO and NRIs for admission into the MDS courses under Management Quota for the academic year 2024-25 into Dental Colleges affiliated to KNR University of Health Sciences in the State of Telangana.

KNRUHS has released a notification detailing the eligibility, fees and other details for the admission.

As per the notification, candidates who are willing to take admission to MDS courses for the academic year 2024-25 can register online and upload scanned original certificates till  23rd August 2024 by 05.00 PM. However, candidates who have secured the following cut-off in the NEET MDS- 2024 examination are only eligible to apply for admission to MDS courses under Management Quota in the State of Telangana.

CUT-OFF

S.NO

CATEGORY

QUALIFYING CRITERIA

CUTT OFF SCORE

1

General category

50th Percentile

263

2

SC/ST/OBC

40th Percentile

230

3

OC/PWD.

45th Percentile

246

FEES

The candidates need to pay Rs.6300/- through a Debit card / Credit card or Net Banking for Registration and Verification. However, the Registration and Verification fee once paid will not be refunded or adjusted to a further date.

Additionally, candidates who completed BDS from other States also need to pay an equivalency fee for verification of the certificate along with the Registration and Verification Fee. The fee for a BDS Degree from another state or other country is Rs. 5,000 & Rs. 7,000 respectively.

DOCUMENTS

While registering, candidates also need to upload the following documents-

1 Latest passport-size photo.

2 Admit card and Score Card NEET-MDS-2024.

3 Original/Provisional BDS Degree Certificate.

4 Aadhar Card.

5 Study Certificate(s) 1st to final BDS.

6 Latest Category certificate in case of BC/SC/ST candidates issued by Competent Authority if applicable (for NEET-MDS-2024 Cut-off score under category for eligibility). However, there is no reservation under the management quota.

7 Internship completion certificate

8 Permanent Dental Council Registration Certificate.

9 Permanent Dental Registration Certificate is mandatory if the candidate obtained a Dental Degree Certificate from outside the country.

10 Candidates claiming NRI quota (MQ2) Should submit the following documents from a Blood relative such as Father/Mother/Brother/Sister/Uncle/Aunt only and should submit a declaration to that effect-

i NRI Sponsorship certificate ( Declaration form).

ii NRI status certificate of the financial supporter issued by the embassy of the respective country under their seal.

iii Copy of NRI Bank account passbook of the financial supporter.

iv Copy of Passport of NRI financial supporter.

11 Sponsorship Certificate from College for Institutional Quota.

12 Documents are required for eligibility in the Army College of Dental Sciences (ACDS)(If applicable).

Along with this, candidates should also submit the print-out of the filled-in online application form and original certificates along with (1) set of self-attested copies to the Principal of the allotted college at the time of admission for final verification. In case of any discrepancy, the provisional allotment order will be cancelled.

ELIGIBILITY

1 Candidate should have qualified in NEET-MDS-2024 by securing the above-mentioned cut-off marks.

2 Candidate should have passed the BDS Degree examination from an Institution recognized by the Dental Council of India.

3 Candidates who have completed their BDS course from an institution outside the country should submit a permanent registration certificate compulsorily.

4 Candidates should have registered with the Dental Council of India/State Dental Council.

MANAGEMENT QUOTA SEATS

1 MDS seat available under Management Quota in Dental Colleges including Army Dental College will be displayed separately on the KNRUHS official website before Online Counseling.

2 Final seat matrix for Management Quota sub-category – MQ.-1, MQ.2, MQ-3 will be displayed on KNRUHS official website before online counselling.

3 MDS seats in Army Dental College are reserved for wards of Army Personnel Only.

To view the notification, click the link below

Powered by WPeMatico

ESI Hospital Vijayawada to be upgraded to 300-bed Hospital

Vijayawada: Minister for Labour and Factories, Vasamsetti Subhash has inaugurated the new premises of the Employees State Insurance (ESI) Hospital at Gunadala in Vijayawada. He announced that the 110-bed ESI hospital in Vijayawada will be upgraded to a 300-bed hospital.

The Minister stated that the hospital has been serving thousands of labour families since 1968, now this will be expanded to a 300-bed capacity. This increasing bed capacity will provide more space to accommodate patients and reduce waiting times for treatment. He further stated that all ESI hospitals across the state would undergo phased development, with comprehensive measures being implemented to ensure this enhancement. This expansion is set to enhance the hospital’s capacity and improve healthcare services for the growing population of the region. 

Also Read: ESIC approves Rs 1128 crore for construction of 7 hospitals, 800 beds to be added

Minister Subhash emphasized that all ESI hospitals will be upgraded to provide comprehensive treatment for various diseases and to ensure prompt medical services for labour families. He also criticized the previous YSRC government for neglecting ESI hospitals over the past five years. He highlighted the issues which caused significant difficulties for the workers such as inadequate equipment and unfilled job vacancies. He also revealed that a vigilance inquiry has been launched to investigate irregularities related to YSR Bhima. This YSR Bhima has allegedly set up its own insurance company, raising concerns about its practices.

Misappropriating funds received from the Centre had caused significant frustration within the labour department. Subhas has accused YSRC of this. He also indicated that efforts are actively underway to expand the ESI scheme to cover every organization with 10 or more workers, intending to significantly boost membership.

According to The New Indian Express, Gadde Rammehan Rao, the MLA of Vijayawada East Constituency has stated that the government would continue to prioritise the labour sector after agriculture. He said that both Central and State governments would allocate funds for labour welfare. Labour, Industries, Boilers, and IMS Secretary M Naik, MLC P Ashok Babu, Karmik Rajya Bima Medical Services Director V Anjaneulu, ESIC Regional Director A Venugopal, and officials from various departments were present.

Also Read: Expansion of ESI Hospitals: ESI Corporation to set up 105 Hospitals

Powered by WPeMatico

Revolutionizing Treatment: Cardiac Shockwave Therapy Enhances Myocardial Function in Ischemic Heart Failure

Austria: In a groundbreaking development for treating ischemic heart failure, researchers have unveiled promising results from the CAST-HF trial, demonstrating that cardiac shockwave therapy (SWT), combined with coronary bypass surgery, significantly improves myocardial function. This innovative approach holds the potential to transform the management of a condition affecting millions worldwide.

The findings from the CAST-HF trial indicate that direct cardiac SWT, in addition to coronary bypass surgery, improves left ventricular ejection fraction (LVEF) and physical capacity at one year in patients with ischaemic heart failure (HF). The findings were published online in the European Heart Journal on June 20, 2024.

Ischemic heart failure arises when the heart muscle receives insufficient blood flow due to narrowed or blocked coronary arteries. Traditional treatments like coronary bypass surgery aim to restore blood flow, but residual myocardial dysfunction often persists, limiting patients’ quality of life and prognosis. Revascularisation strategies control symptoms but are less effective in improving LVEF.

Against the above background, Johannes Holfeld, Medical University of Innsbruck, Anichstrasse, Innsbruck, Austria, and colleagues aimed to investigate the safety of cardiac shockwave therapy as a novel treatment option and its efficacy in increasing cardiac function by inducing angiogenesis and regeneration in hibernating myocardium.

For this purpose, the researchers enrolled patients with LVEF ≤40% requiring surgical revascularization in a single-blind, parallel-group, sham-controlled trial.

Patients were randomly assigned to undergo direct cardiac shockwave therapy or sham treatment in addition to coronary bypass surgery. The main measure of effectiveness was the improvement in LVEF as assessed by cardiac magnetic resonance imaging from the start of the study to day 360.

The study led to the following findings:

  • Sixty-three patients were randomized, of which 30 patients of the SWT group and 28 patients of the Sham group attained 1-year follow-up of the primary endpoint.
  • There was greater improvement in LVEF in the SWT group (Δ from baseline to 360 days: SWT 11.3%, SD 8.8; Sham 6.3%).
  • Secondary endpoints included the 6-minute walking test, where patients randomized in the SWT group showed a greater Δ from baseline to 360 days (127.5 m) than patients in the Sham group (43.6 m) and Minnesota Living with Heart Failure Questionnaire score on day 360, which was 11.0 points for the SWT group and 17.3 points for the Sham group.
  • Two patients in the treatment group died for non-device-related reasons.

The study showed that SWT, in addition to CABG, is a promising novel therapeutic option for patients suffering from ischaemic cardiomyopathy.

“The results of the CAST-HF trial indicate that this therapeutic approach may address the significant clinical challenge of myocardial regeneration in individuals with ischemic heart failure,” the researchers wrote.

“Additional studies with larger participant groups in this patient cohort are necessary to determine if the positive impacts of direct cardiac shockwave therapy on myocardial function lead to improved clinical outcomes, as observed in the current trial,” they concluded.

Reference:

Holfeld, J., Nägele, F., Pölzl, L., Engler, C., Graber, M., Hirsch, J., Schmidt, S., Mayr, A., Troger, F., Pamminger, M., Theurl, M., Schreinlechner, M., Sappler, N., Schaden, W., Cooke, J. P., Ulmer, H., Bauer, A., & Grimm, M. Cardiac shockwave therapy in addition to coronary bypass surgery improves myocardial function in ischaemic heart failure: The CAST-HF trial. European Heart Journal. https://doi.org/10.1093/eurheartj/ehae341

Powered by WPeMatico

Mild Weight Gain After Quitting Smoking Raises T2DM Risk in Men with NAFLD, Study Reveals

China: A new study has highlighted the increased risk of developing type 2 diabetes (T2DM) in men with non-alcoholic fatty liver disease (NAFLD) who gain weight after quitting smoking. This research, which followed participants over seven years, underscores the importance of weight management for those with NAFLD who have recently stopped smoking.

The study, published in Diabetology & Metabolic Syndrome, found that men with NAFLD who gain weight after quitting smoking are at a significantly higher risk of developing type 2 diabetes.

“Among 1,409 NAFLD patients, those who gained 4 kg or more post-cessation experienced up to a six-fold increase in their risk of T2DM compared to current smokers. Effective weight management is essential for NAFLD patients after quitting smoking to help reduce their risk of developing T2DM,” the researchers wrote.

NAFLD, a condition characterized by the accumulation of fat in the liver unrelated to alcohol consumption, has been associated with an increased risk of various metabolic disorders, including type 2 diabetes. Chengfu Xu, Zhejiang Provincial Clinical Research Center for Digestive Diseases, Hangzhou, China, and colleagues aimed to investigate the post-cessation T2DM risk in male NAFLD and NAFLD-free smokers in a 7-year cohort study.

The study included male adults who participated in annual health checkups over seven years. Recent quitters were divided into four groups based on their weight gain during follow-up: <0 kg, 0–1.9 kg, 2.0–3.9 kg, and ≥4.0 kg. Cox proportional hazard models, adjusted for various factors, were employed to calculate hazard ratios (HRs) and evaluate the relationship between post-cessation weight gain and the development of type 2 diabetes in both NAFLD and NAFLD-free individuals.

The study led to the following findings:

  • At baseline, the study included 1,409 NAFLD and 5150 NAFLD-free individuals.
  • During a total of 39,259 person-years of follow-up, 15.8% NAFLD patients and 12.1% NAFLD-free participants quit smoking, with the corresponding means (standard deviations) of post-cessation weight gain being 2.24 kg and 1.15 kg, respectively.
  • Among NAFLD individuals, compared to current smokers, the fully adjusted HRs for incident T2DM were 0.41, 2.39, 4.48, and 6.42 for quitters with weight gains < 0 kg, 0.0–1.9 kg, 2.0–3.9 kg, and ≥ 4.0 kg, respectively.
  • For NAFLD-free individuals, we only observed a significant association between post-cessation weight gain ≥ 4.0 kg and the risk of incident T2DM.
  • Further analysis revealed that the impact of post-cessation weight gain on T2DM risk was not affected by alcohol consumption or obesity status at baseline.

“The findings showed that mild weight gain following smoking cessation markedly raised the risk of type 2 diabetes in men with NAFLD, but not in those without the condition. Consequently, it is advised that individuals with NAFLD focus on managing their weight after quitting smoking to mitigate their risk of developing T2DM,” the researchers concluded.

Reference:

Xie, J., Lin, P., Hou, L. et al. Risk of incident type 2 diabetes in male NAFLD and NAFLD-free smokers: a 7-year post-cessation study. Diabetol Metab Syndr 16, 192 (2024). https://doi.org/10.1186/s13098-024-01435-4

Powered by WPeMatico

Routine Protamine Use Enhances Hemostasis and Reduces Complications After TAVI, ACE-PROTAVI Trial Finds

Australia: Administering protamine routinely at the end of transcatheter aortic valve replacement (TAVR) or implantation (TAVI) results in faster and more effective hemostasis for patients, findings from the ACE-PROTAVI trial have shown.

“In the ACE-PROTAVI randomized clinical trial involving 410 patients across three Australian hospitals, routine administration of protamine after TAVI resulted in a higher rate of successful hemostasis and a lower incidence of vascular complications compared to placebo,” the researchers reported in JAMA Cardiology.

Vascular complications following transfemoral TAVI continue to be a significant source of procedure-related morbidity. Routine use of protamine to reverse anticoagulation at the end of transfemoral TAVI has the potential to reduce these complications, though evidence on its effectiveness is limited. To fill this knowledge gap, Pieter A. Vriesendorp, Heart Centre, The Alfred Hospital, Melbourne, Australia, and colleagues aimed to evaluate the safety and efficacy of routine protamine administration after transfemoral TAVI.

The ACE-PROTAVI trial was an investigator-initiated, double-blind, placebo-controlled randomized clinical trial conducted at three Australian hospitals from December 2021 to June 2023, with a follow-up period of one year. Patients eligible for transfemoral TAVI, as determined by a multidisciplinary heart team, were included in the study.

Participants were randomly assigned in a 1:1 ratio to receive either routine protamine administration or a placebo. The coprimary outcomes were the rate of hemostasis success and the time to hemostasis (TTH). These outcomes were analyzed as categorical variables using a χ2 test or as continuous variables, presented as means (SD) or medians (IQR), depending on their distribution.

The major secondary outcome was a composite measure of all-cause death, major and minor bleeding complications, and major and minor vascular complications occurring after 30 days.

The following were the key findings of the study:

  • The study population comprised 410 patients: 199 patients in the protamine group and 211 in the placebo group. The median patient age in the protamine group was 82 years, and 68 of 199 patients receiving protamine (34.2%) were female. The median patient age in the placebo group was 80 years, and 89 of 211 patients receiving the placebo (42.2%) were female.
  • Patients receiving up-front protamine administration had a higher rate of hemostasis success (97.9%) than patients in the placebo group (91.6%; absolute risk difference, 6.3%); in addition, patients receiving up-front protamine had a shorter median TTH (181 seconds versus 279 seconds).
  • Routine protamine administration led to a reduced risk of the composite outcome in the protamine group (5.2%) versus the placebo group (12.8%; OR, 0.37). This difference was predominantly driven by the difference in the prevalence of minor vascular complications.
  • There were no adverse events associated with protamine use.

In the ACE-PROTAVI randomized clinical trial, routine protamine administration improved the rate of hemostasis success and reduced the time to hemostasis. Additionally, patients who received protamine experienced fewer minor vascular complications, shorter procedural times, and reduced post-procedural hospital stays versus those who received a placebo.

Reference:

Vriesendorp PA, Nanayakkara S, Heuts S, et al. Routine Protamine Administration for Bleeding in Transcatheter Aortic Valve Implantation: The ACE-PROTAVI Randomized Clinical Trial. JAMA Cardiol. Published online August 14, 2024. doi:10.1001/jamacardio.2024.2454

Powered by WPeMatico

Weight-loss success may depend on eating more protein, fiber while limiting calories, study says

Participants on a self-directed dietary education program who had the greatest success at losing weight across a 25-month period consumed greater amounts of protein and fiber, a study found. Personalization and flexibility also were key in creating plans that dieters could adhere to over time.

At the one-year mark, successful dieters (41% of participants) had lost 12.9% of their body weight, compared with the remainder of the study sample, who lost slightly more than 2% of their starting weight, according to a paper on the study published in Obesity Science and Practice.

The dieters were participants in the Individualized Diet Improvement Program, which uses data visualization tools and intensive dietary education sessions to increase dieters’ knowledge of key nutrients, enabling them to create a personalized, safe and effective weight-loss plan, said Manabu T. Nakamura, a professor of nutrition at the University of Illinois Urbana-Champaign and the leader of the research.

“Flexibility and personalization are key in creating programs that optimize dieters’ success at losing weight and keeping it off,” Nakamura said. “Sustainable dietary change, which varies from person to person, must be achieved to maintain a healthy weight. The iDip approach allows participants to experiment with various dietary iterations, and the knowledge and skills they develop while losing weight serve as the foundation for sustainable maintenance.”

The pillars of iDip are increasing protein and fiber consumption along with consuming 1,500 calories or less daily.

Based on the dietary guidelines issued by the Institutes of Medicine, the iDip team created a one-of-a-kind, two-dimensional quantitative data visualization tool that plots foods’ protein and fiber densities per calorie and provides a target range for each meal. Starting with foods they habitually ate, the dieters created an individualized plan, increasing their protein intake to about 80 grams and their fiber intake to about 20 grams daily.

In tracking the participants’ eating habits and their weights with Wi-Fi enabled scales, the team found strong inverse correlations between the percentages of fiber and protein eaten and dieters’ weight loss.

“The research strongly suggests that increasing protein and fiber intake while simultaneously reducing calories is required to optimize the safety and efficacy of weight loss diets,” said first author and U. of I. alumna Mindy H. Lee, a then-graduate student and registered dietitian-nutritionist for the iDip program.

Nakamura said the preservation of lean mass is very important while losing weight, especially when using weight-loss drugs.

“Recently, the popularity of injectable weight loss medications has been increasing,” Nakamura said. “However, using these medications when food intake is strongly limited will cause serious side effects of muscle and bone loss unless protein intake is increased during weight loss.”

A total of 22 people who enrolled in the program completed it, including nine men and 13 women. Most of the dieters were between the ages of 30-64. Participants reported they had made two or more prior attempts to lose weight. They also had a variety of comorbidities-54% had high cholesterol, 50% had skeletal problems and 36% had hypertension and/or sleep apnea. Additionally, the dieters reported diagnoses of diabetes, nonalcoholic fatty liver disease, cancer and depression, according to the study.

The seven dieters who reported they had been diagnosed with depression lost significantly less weight-about 2.4% of their starting weight compared with those without depression, who lost 8.39% of their initial weight. The team found that weight loss did not differ significantly among participants with other comorbidities, or between younger and older participants or between men and women.

Body composition analysis indicated that dieters maintained their lean body mass, losing an average of 7.1 kilograms of fat mass and minimal muscle mass at the six-month interval. Among those who lost greater than 5% of their starting weight, 78% of the weight they lost was fat, according to the study.

Overall, the participants reduced their fat mass from an average of 42.6 kilograms at the beginning of the program to 35.7 kilograms at the 15-month mark. Likewise, the dieters reduced their waists by about 7 centimeters at six months and by a total of 9 centimeters at 15 months, the team found.

In tracking dieters’ protein and fiber intake, the team found a strong correlation between protein and fiber consumption and weight loss at three months and 12 months.

“The strong correlation suggests that participants who were able to develop sustainable dietary changes within the first three months kept losing weight in the subsequent months, whereas those who had difficulty implementing sustainable dietary patterns early on rarely succeeded in changing their diet in the later months,” Nakamura said.

The team hypothesized that this correlation could also have been associated with some dieters’ early weight loss success, which may have bolstered their motivation and adherence to their program.

Reference:

Mindy H. Lee, Annabelle Shaffer, Nouf W. Alfouzan, Catherine C. Applegate, Jennie C. Hsu, John W. Erdman Jr., Manabu T. Nakamura, Successful dietary changes correlate with weight-loss outcomes in a new dietary weight-loss program, Obesity Science & Practice, https://doi.org/10.1002/osp4.764.

Powered by WPeMatico

Telehealth Mindfulness-Based Interventions Prove Effective for Veterans with Chronic Pain: The LAMP Trial

USA: In a recent study, the LAMP Randomized Clinical Trial has demonstrated that scalable, low-resource mindfulness-based interventions (MBIs) delivered via telehealth can significantly benefit veterans suffering from chronic pain. The multisite trial explored the effectiveness of these virtual MBIs in improving pain-related function and biopsychosocial outcomes, particularly among those with high levels of psychiatric comorbidity.

In their study, published in JAMA Internal Medicine, the researchers reported that both group-based and self-paced MBIs enhanced pain-related function and biopsychosocial outcomes in veterans with chronic pain and significant psychiatric comorbidities. Specifically, the probability of achieving a 30% improvement from baseline was higher for group MBIs at ten weeks and six months, while self-paced MBIs showed greater improvements at ten weeks, six months, and one year.

Chronic pain is a pervasive issue among veterans, often compounded by psychological distress and limited access to traditional therapeutic resources. While mindfulness-based interventions are proven treatments for chronic pain and related conditions, scaling their implementation presents significant challenges, including the need for dedicated space and trained instructors. Considering this, Diana J. Burgess, University of Minnesota Medical School, Minneapolis, and colleagues aimed to examine group and self-paced, scalable, telehealth MBIs for veterans with chronic pain compared to usual care.

For this purpose, the researchers conducted a randomized clinical trial from November 2020 to May 2022 with veterans suffering from moderate to severe chronic pain across three Veterans Affairs facilities. They compared two 8-week telehealth MBIs with usual care. The interventions included a group MBI, delivered via videoconference with prerecorded mindfulness education, skill training videos, facilitated discussions by an experienced instructor, and a self-paced MBI, which was completed asynchronously and supplemented by three individual facilitator calls. Follow-up was completed in August 2023.

The primary outcome measured was pain-related function, assessed using the Brief Pain Inventory interference scale at 10 weeks, 6 months, and 1 year. Secondary outcomes examined included pain intensity, physical function, anxiety, fatigue, sleep disturbance, participation in social roles and activities, depression, patient ratings of pain improvement, and posttraumatic stress disorder.

The study led to the following findings:

  • Among 811 veterans randomized (mean age, 54.6 years; 47.7% women), 85.6% of participants completed the trial.
  • Averaged across all 3-time points, pain interference scores were significantly lower for both MBIs than usual care (group MBI versus control difference: −0.4; self-paced versus control difference: −0.7).
  • Both MBI arms had significantly better scores on the following secondary outcomes: pain intensity, patient global impression of change, physical function, fatigue, sleep disturbance, social roles and activities, depression, and posttraumatic stress disorder.
  • Both group and self-paced MBIs did not significantly differ from one another.
  • The probability of 30% improvement from baseline compared to control was greater for group MBI at ten weeks and six months, and for self-paced MBI at all three time points.

In the randomized clinical trial, scalable telehealth mindfulness-based interventions enhanced pain-related function and biopsychosocial outcomes more effectively than usual care for veterans with chronic pain.

“These low-resource telehealth-based MBIs could significantly expedite and improve the integration of nonpharmacological pain treatments into healthcare systems,” the researchers concluded.

Reference:

Burgess DJ, Calvert C, Hagel Campbell EM, et al. Telehealth Mindfulness-Based Interventions for Chronic Pain: The LAMP Randomized Clinical Trial. JAMA Intern Med. Published online August 19, 2024. doi:10.1001/jamainternmed.2024.3940

Powered by WPeMatico