Aurobindo Pharma receives tax demand of over Rs 13 crore, including interest, penalty

New Delhi: Aurobindo Pharma Ltd has been issued a tax demand exceeding Rs 13 crore by the GST authority. This demand encompasses both interest and penalties and relates to the company’s ineligible input tax credit claim.

The Deputy Commissioner (ST) STU-1 of GST, Punjagutta Division, Hyderabad, Commercial Taxes Department, Telangana, has passed an order under relevant provisions of the Central Goods and Services Tax Act, 2017 and TGST Act 2017 for the FY 2018-19 demanding reversal of ITC and payment of GST amounting to Rs. 6,54,50,645 along with interest of Rs.5,92,20,900/-. A penalty of Rs. 65,51,354.

It claims ineligible ITC and orders reversal of ITC and demanding GST along with interest, the company stated.

The Company is intending to file appeal before Appellate Authority, Aurobindo Pharma stated in a BSE filing.

Read also: Aurobindo Pharma appoints T Vijaya Kumar as President – RnD (Specialty Drug Delivery)

There is no material impact on the Company financials or operations due to the said order, the Company further added.

Medical Dialogues team had earlier reported that Sun Pharmaceutical Industries had been served with a tax demand of over Rs 1.11 crore by authorities, citing disallowed input tax credit.

Read also: Sun Pharma served with tax demand of Rs 1.11 crore

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Medical Bulletin 04/ May/ 2024

Here are the top medical news for the day:

Time-restricted eating and high-intensity exercise may synergistically enhance health

Researchers from the University of Sfax in Tunisia discovered that combining time-restricted eating with high-intensity functional training may improve body composition and cardiometabolic parameters more than either practice alone.

The study published in the journal PLOS ONE explained that time-restricted eating limits when individuals eat but not what individuals eat. High-intensity functional training combines intense aerobic and resistance exercise.

Time-restricted eating involves limiting food intake to specific windows of time, promoting metabolic flexibility and weight management. High-intensity exercise, characterized by short bursts of intense activity, enhances cardiovascular fitness, muscle strength, and metabolic rate. When integrated, these approaches may optimize insulin sensitivity, blood sugar control, and lipid metabolism. Additionally, the combination may promote fat loss, muscle growth, and cellular repair mechanisms.

In the study, researchers assigned 64 women with obesity to one of three groups: time-restricted eating (diet only), high-intensity functional training (exercise only), or time-restricted eating plus high-intensity functional training (diet and exercise).The participants following only the time-restricted eating regimen ate only between 8 a.m. and 4 p.m. Subjects in the functional training groups worked out three days a week with an instructor.

The results showed that all three groups experienced significant weight loss and decreases in waist and hip circumference after 12 weeks. All three groups also showed positive changes in glucose and lipid levels.

Researchers also observed improvementsin fat-free mass and blood pressure among those in the diet and exercise group as well as the exercise groups. However, those improvements weren’t seen in the diet-only group.Subjects in the diet and exercise group generally saw more pronounced changes in body composition and cardiometabolic parameters than either diet or exercise alone groups.

“Periods of fasting force the body to burn calorie reserves – fat, after immediate reserves are consumed – and intense physical activity also burns fat. Time of eating can affect a person’s weight. Consuming a larger number of calories later in the day can leave less time for a body to metabolize calories, as there is less calorie consumption when you sleep. Although more research is needed, it’s believed that eating in alignment with circadian rhythms might enhance metabolism, although the ideal timing for meals can vary based on individual lifestyle and metabolic differences,” said the study authors.

Reference:Ranya Ameur ,Rami Maaloul ,SémahTagougui,FadouaNeffati,Faten Hadj Kacem,Mohamed Fadhel Najjar,AchrafAmmar,Omar Hammouda; Unlocking the power of synergy: High-intensity functional training and early time-restricted eating for transformative changes in body composition and cardiometabolic health in inactive women with obesity; PLOS ONE; https://doi.org/10.1371/journal.pone.0301369

Study suggest staying active to boost quality of life in middle-aged women

According to a new study published in the open-access journal PLOS Medicine, consistent adherence to physical activity guidelines throughout middle-age is associated with a higher health-related quality of life in women.

Staying active during middle age offers numerous benefits that significantly enhance the quality of life for women. Regular physical activity during this life stage helps maintain cardiovascular health by reducing the risk of conditions like heart disease and stroke. It also supports healthy weight management, which is crucial for overall well-being and reducing the risk of obesity-related health issues. Additionally, staying active improves muscle strength, flexibility, and bone density, reducing the risk of osteoporosis and age-related muscle loss.

In the study, researchers used data collected at three-year intervals beginning in 1996 from 11,336 participants in the Australian Longitudinal Study on Women’s Health. Participants were classified as either meeting WHO physical activity guidelines — of 150 minutes of activity a week — consistently throughout the fifteen-year exposure period. Health-related quality of life was assessed using the physical health composite score (PCS) and mental health composite score (MCS), which included questions about functional health and well-being.

The results revealed that on average, people who consistently met physical activity guidelines and those who first started to meet guidelines at age 55 had a three-point higher PCS compared to those that did not meet physical activity guidelines. The effect of physical activity on the PSC was significant even after controlling for socioeconomic factors and pre-existing health diagnoses. However, there was no significant association between physical activity and MCS.

“Combined with existing evidence, this study contributes to growing evidence of the benefits of maintaining or adopting an active lifestyle in mid-age,” the authors say. “An important public health message is that being active for as many years as possible, even if women start to meet physical activity guidelines in their mid-50s, could have important health benefits in terms of physical health, especially in physical functioning.Our study shows that it’s important for women to be active throughout mid-age to gain the most benefits for physical health in later life. Ideally, women should increase their activity levels to meet the guidelines by age 55,” said the study authors.

Reference:Binh Nguyen ,PhilipClare,Gregore I. Mielke,Wendy J. Brown,Ding Ding; Physical activity across midlife and health-related quality of life in Australian women: A target trial emulation using a longitudinal cohort; PLOS Medicine; https://doi.org/10.1371/journal.pmed.1004384

Children with hypertension at higher risk for heart conditions, finds study

According to a study being presented at the Pediatric Academic Societies (PAS) 2024 Meeting, youth with high blood pressure are nearly four times more likely to be at long-term risk of serious heart conditions including stroke and heart attack.

Hypertension affects one of every 15 children and adolescents worldwide and is a growing concern, according to previous researches. A child is diagnosed with hypertension when their average blood pressure is at or above the 95th percentile for their age, sex and height. While the reason for the increase in pediatric hypertension is not entirely clear, it is considered to be due to obesity.

High blood pressure can cause many heart conditions, including:

1. Coronary artery disease where the arteries that supply blood to the heart are narrowed and damaged. Too little blood flow to the heart can lead to chest pain, called angina and cause irregular heart rhythms.

2.Heart failure where the heart muscle weakens or becomes stiff and functions poorly.

3. Metabolic syndrome, which is a cluster of health conditions that can lead to stroke or diabetes.

The study found that during an average follow-up of 13 years, youth with hypertension were at two to four times higher risk of experiencing heart attack, stroke, heart failure, or cardiac surgery compared to youth without hypertension. Experts said that improved blood pressure screening and treatment during childhood may reduce the risk of serious cardiovascular disease as an adult.

“Devoting more resources to pediatric blood pressure screening and control could lower the risks of long-term heart conditions in children with hypertension. More awareness about the importance of regular screening and follow-up for pediatric hypertension may prevent children from developing significant adverse heart outcomes later in life”said Cal H. Robinson, MD, pediatric nephrology fellow at The Hospital for Sick Children (SickKids) and presenting author.

Reference:Cal H. Robinson, MD et al.; Long-term cardiovascular outcomes in children and adolescents with hypertension: A population-based, propensity-matched cohort study; Pediatric Academic Societies (PAS) Meetingheld May 3-6 in Toronto.

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Private Practice during Duty Hours: Principal GMC Handwara warns doctors of termination

Srinagar: Taking strict action against government doctors practising privately, Professor Dr Khurshid Ahmad Wani, the recently appointed Principal of Government Medical College Handwara, has issued a stern warning to all doctors of its Associated Hospitals of immediate termination without any prior notice if they are found practising during working hours. 

An order issued by him in this regard mentioned, “It is for the information of all the faculty/doctors of GMC Handwara and its associated hospitals that if any of them are found practising privately during working hours, he/she will be terminated immediately without any prior notice.”

Additionally, Dr Khurshid mentioned a specific time frame for doctors to follow the directive of not engaging in private practice, which is from 9 am to 5 pm. This bold move was made in response to complaints about doctors practising privately during their official working hours, leading to inconvenience for their patients. Hence, this move is expected to bring relief to the patients. 

Also read- GMC Anantnag, Handwara Gets New Principals

Medical Dialogues had recently reported that the Health and Medical Education Department in Jammu and Kashmir made Dr Khurshid Wani the new Principal of Government Medical College (GMC) Handwara. Dr Khurshid Wani was appointed as Principal of Government Medical College Handwara after Dr Iffat Hassan was relieved from the post of principal.

Speaking to Rising Kashmir, Dr Khurshid Ahmad Wani said, “The motive behind this order is to provide better healthcare facilities to the people of the district. It is worth noting that frequent complaints of doctors practising privately during official hours were being reported from the associated hospital of GMC Handwara. With this order, the people of Kupwara district hope to receive better facilities.”

Dr Wani has further emphasized that his main focus will be on academics and enhancing healthcare facilities. Additionally, he has instructed the hospital administration to regularly monitor the attendance of paramedical staff.

Also read- MP: 18 Government Medical Colleges Get New Dean

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Patanjali Ayurved to take legal action against Uttarakhand SLA

In a recent update amid the misleading ads controversy, Patanjali Ayurved has called for legal action against the decision of the Uttarakhand State Licensing Authority (SLA) to suspend manufacturing licenses of 14 products of Patanjali Ayurved Ltd and Divya Pharmacy.

On Tuesday, the Uttarakhand SLA informed the Supreme Court that the order was issued to Baba Ramdev’s company after repeated violations of the drug advertisements law.

For more details, check out the full story on the link below:

Licences Of 14 Products Suspended: Patanjali Ayurved Calls For Legal Action Against Uttarakhand SLA


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GMC Akola Surgery Residents Assaulted, Doctors Demand Enhanced Security in all Maha Medical Colleges

Akola: In yet another instance of violence against doctors, three Surgery resident doctors from the Government Medical College (GMC) Akola were recently assaulted by the relatives of a patient.

The incident happened yesterday when around 20-25 people came inside the hospital and attacked the doctors with slippers and rods after the patient collapsed. Following this, the resident doctors at the institute initiated a strike closing the OPD services.

The resident doctors have demanded the authorities increase guard security and CCTV facilities and have also filed a police complaint regarding the incident, the President of the Maharashtra Association of Resident Doctors (MARD) at GMC Akola, Dr. Henry informed Medical Dialogues.

He said that the patient was a known case of Hemophilia and the doctors provided their best care to the patient. However, despite all the possible measures, the patient collapsed. After he was declared to be dead, several people came inside and assaulted the surgery residents.

“Once the incident happened, we gave an intimation to our administration that we were going into a strike,” he said, adding that considering the patients, the emergency services have been kept operational and only OPD services have been closed.  However, if the situation continues, then the doctors will be forced to go for the shutting down of the emergency services as well, he added.

Also Read: Puducherry Shocker: Ophthalmology Resident doctor brutally attacked with knife, sustains severe neck injury, 18 sutures

Central MARD Extends its Support: 

Meanwhile, Maharashtra State Association of Resident Doctors (Central MARD) has also extended its support to the doctors. Issuing a Press Release today, Central MARD mentioned, “We are deeply disturbed by the reports of the assault on a Surgery resident doctor at Government Medical College & Hospital, Akola, which occurred on May 3, 2024. This act of violence against a member of the medical community is unacceptable and we strongly condemn it in the strongest terms.”

“The safety and security of healthcare professionals are of utmost importance. They are at the forefront of providing essential services to the community, often under challenging circumstances. Any form of violence against them is not only a crime against the individuals but also an attack on the sanctity of the medical profession and public health at large,” the release further added.

Extending its solidarity with the resident doctors and the entire medical fraternity at GMC Akola, the association has urged the authorities to take swift and decision action to ensure that the perpetrators are brought to justice. Furthermore, Central MARD demanded immediate measures to enhance the security at medical colleges and hospitals to prevent such incidents in the future.

MARD Demands Enhanced Security Measures at Maha Medical Colleges: 

Raising the issue, Central MARD today wrote to the Maharashtra DMER Commissioner and requested the authorities to ensure enhanced security measures at medical colleges in the State of Maharashtra.

Condemning the incident of violence against the doctors at GMC Akola, Central MARD pointed out in the letter that in recent times, there have been several reports of security breaches and incidents that have raised concerns about the safety of the students, faculty, and staff within the premises of the medical institutes.

“These incidents not only threaten the physical well-being of individuals but also disrupt the academic environment, which is crucial for the nurturing of future medical professionals,” the association mentioned in the letter.

Highlighting the need for a secure and safe educational setting, MARD pointed out that it is the responsibility of the administration to ensure that robust security measures are in place.

“It is high time to strengthen the security measures at all medical colleges and hospitals in the state of Maharashtra and the administration should not wait till the next incident of assault on resident doctors,” it mentioned in the letter.

Urging the authorities to ensure increased security, the association added, “CENTRAL MARD requests the administration to stringently look into the security of each and every medical college and hospital and ensure that the resident doctors who are the most important pillars of healthcare in India are safe.”

Commenting on the matter, the President of Central MARD, Dr. Abhijit Helge told Medical Dialogues, “We have requested the commissioner of medical education to provide enhanced security measures at the earliest across all medical colleges in the state of Maharashtra.”

Also Read: NHRC highlights rights of patients and doctors, raises concern on violence against medical professionals

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Mob Attack: 2 Surgeons brutally attacked after patient death, admitted in ICU

Kolkata: Two on-duty doctors of the surgery department at Tamluk Medical College and Hospital were allegedly attacked by the relatives of a patient who died during treatment in their hospital on Thursday.  

The incident occurred on Thursday when the patient was admitted and five people allegedly involved in the assault at a state-run hospital in West Bengal’s Purba Medinipur district were arrested.

According to a PTI report, The two doctors of the surgery department at Tamluk Medical College and Hospital are undergoing treatment at the ICU of the same medical facility, police said.

Based on the complaints lodged by fellow doctors and several video clips recorded by them, police arrested five people.

Also Read:Ahmedabad hospital vandalized, Two doctors assaulted after death of patient

The footage captured a group of unidentified individuals wielding bamboo sticks while assaulting the doctors near the boys’ hostel of the medical institution.

The doctors were attacked following the death of Shiekh Arif Ali, who was brought to the hospital after a motorbike accident at around 9.15 pm on Wednesday, the police officer said.

He said, “Ali’s condition improved after doctors treated him. But his family members took him away without the consent of the hospital. After an hour or so, he was brought back to the hospital. Doctors found him brought dead,” reports news agency PTI.

Thereafter, the family members started assaulting the doctors on duty, the officer added. 

Police are investigating the matter.  

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New approach for developing cancer vaccines could make immunotherapies more effective in acute myeloid leukemia

Acute myeloid leukemia (AML) is a type of blood cancer that forms in the soft marrow of the bones, typically attacking cells that would otherwise form the key component of the body’s immunodefense system, white blood cells.

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Drug targeting RNA modifications shows promise for treating neuroblastoma

Neuroblastoma is a common pediatric cancer that originates in developing nerve cells outside the brain. While increasingly intensive treatments have improved the survival of patients with high-risk neuroblastoma, currently more than 40% of patients do not survive.

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Researchers discover compounds produced by gut bacteria that can treat inflammation

Researchers at the University of Toronto have found naturally occurring compounds in the gut that can be harnessed to reduce inflammation and other symptoms of digestive issues. This can be achieved by binding the compounds to an important, but poorly understood, nuclear receptor.

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How cancer cells harness energy to drive disease progression

Researchers have revealed crucial insights into how the Warburg effect causes the dedifferentiation of cancer cells through epigenetic reprogramming. This discovery potentially opens up new avenues for cancer treatments that target cellular metabolism.

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